利拉鲁肽联合地特胰岛素对肥胖2型糖尿病患者氧化应激与糖脂代谢的影响  

The Influence of Liraglutide Combined with Insulin Detemir for Oxidative Stress and Glycolipid Metabolism of Obese Patients with Type 2 Diabetes Mellitus

作　　者：李洁[1] 黄春[1] 宋宇玲 许淑贤[1] 赵燕妮 LI Jie;HUANG Chun;SONG Yuling;XU Shuxian;ZHAO Yanni(Zhanjiang Central People's Hospital,Zhanjiang 524000,China)

机构地区：[1]广东省湛江中心人民医院,广东湛江524000

出　　处：《中国医学创新》2020年第12期58-61,共4页Medical Innovation of China

基　　金：湛江市科技计划项目(2019B101)。

摘　　要：目的:研究利拉鲁肽联合地特胰岛素对肥胖2型糖尿病患者氧化应激与糖脂代谢的影响。方法:选取2018年12月-2019年8月本院收治的60例肥胖2型糖尿病患者为研究对象,将其随机分为对照组和观察组,各30例。对照组应用地特胰岛素治疗,观察组应用利拉鲁肽联合地特胰岛素治疗。比较两组治疗前后的氧化应激指标、糖代谢及脂代谢指标。结果:治疗前,两组各氧化应激指标、糖代谢指标、脂代谢指标比较,差异均无统计学意义(P>0.05)。治疗6、12周后,观察组各项氧化应激指标、糖代谢指标、脂代谢指标均显著优于对照组,差异均有统计学意义(P<0.05)。结论:利拉鲁肽联合地特胰岛素可显著改善肥胖2型糖尿病患者氧化应激与糖脂代谢状态,在肥胖2型糖尿病患者中的应用价值较高。Objective:To study the effect of Liraglutide combined with Insulin Detemir on oxidative stress and glycolipid metabolism in obese type 2 diabetic mellitus patients.Method:A total of 60 obese type 2 diabetic mellitus patients admitted to our hospital from December 2018 to August 2019 were selected as the research objects,they were randomly divided into control group and observation group,30 cases in each group.The control group was treated with Insulin Detemir,the observation group was treated with Liraglutide combined with Insulin Detemir.The indexes of oxidative stress,glucose metabolism and lipid metabolism were compared before and after treatment.Result:Before treatment,the indexes of oxidative stress,glucose metabolism and lipid metabolism were compared between the two groups,there were no significant differences(P>0.05).After 6 and 12 weeks of treatment,the indexes of oxidative stress,glucose metabolism and lipid metabolism in the observation group were significantly better than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The combination of Liraglutide and Insulin Detemir can significantly improve oxidative stress and glycolipid metabolism in obese type 2 diabetic patients,the application value in obese type 2 diabetic mellitus patients is higher.

关 键 词：利拉鲁肽 地特胰岛素 肥胖2型糖尿病 氧化应激 糖代谢 脂代谢 

分 类 号：R587.1[医药卫生—内分泌]