骨康方联合经皮穿刺椎体成形术治疗骨质疏松性椎体压缩骨折的疗效观察  

Clinical Effect Observation of Gukang Formula Combined with Percutaneous Vertebroplasty in the Treatment of Osteoporotic Vertebral Compression Fractures

作　　者：刘栋华 唐望 焦锋 黄荷 张宏艺 LIU Donghua;TANG Wang;JIAO Feng;HUANG He;ZHANG Hongyi(Guangzhou Integrated Chinese and Western Medicine Hospital,Guangzhou 510800,China)

机构地区：[1]广州市中西医结合医院,广东广州510800

出　　处：《中国医学创新》2020年第12期86-90,共5页Medical Innovation of China

基　　金：广州市科学技术局课题(201904010231);广东省广州市花都区科技工业与信息化局基金课题(17-HDWS-003)。

摘　　要：目的:观察经皮穿刺椎体成形术联合骨康方治疗骨质疏松性椎体压缩骨折的临床效果。方法:将2015年1月-2017年12月本院收治的150例骨质疏松性椎体压缩骨折患者随机分为观察组和对照组,每组75例。两组均采用经皮穿刺椎体成形术,同时给予基础治疗,观察组术后服用骨康方6周,观察治疗前后疼痛视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)、骨密度、Cobb角、椎体压缩率及血清骨代谢标志物变化。结果:两组术后3 d VAS评分、ODI评分均较术前明显改善(P<0.05),两组术后3 d VAS评分、ODI评分比较,差异均无统计学意义(P>0.05);观察组术后3、6个月VAS评分、ODI评分均较对照组改善明显,差异均有统计学意义(P<0.05)。两组术后3、6、12个月骨密度均较术前改善,但术后3个月与术前比较差异无统计学意义(P>0.05);观察组术后6、12个月骨密度均较对照组增加明显,差异均有统计学意义(P<0.05)。两组术后3 d Cobb角及椎体压缩率均较术前有所改善(P<0.05),但两组比较差异均无统计学意义(P>0.05);两组术后3、6个月Cobb角和椎体压缩率均较术后3 d有所增加,但观察组术后6个月Cobb角和椎体压缩率改善情况均较对照组更为显著(P<0.05)。两组术后3、6个月血清骨钙素(bone glaprotein,BGP)和25羟维生素D3[25-hydroxyvitamin D3,25(OH)D3]水平均较术前上升,观察组术后6个月上升更明显(P<0.05)。结论:经皮穿刺椎体成形术联合骨康方治疗骨质疏松性椎体压缩骨折效果显著,可明显缓解疼痛,提高骨密度,改善日常生活能力,具有较高的临床运用价值。Objective:To explore the effect of Gukang Formula combined with percutaneous vertebroplasty(PVP)in the treatment of osteoporotic vertebral compression fractures.Method:A total of150 patient with osteoporotic vertebral compression fractures treated in our hospital from January 2015 to December 2017 were randomly divided into the control group and the experimental group,75 cases in each group.After PVP operation,all patients were treated with routine treatment,beyond that the observation group was treated with Gukang Formula for 6 weeks.The VAS scores,ODI,BMD,Cobb angle,vertebral compression rate and the level of bone metabolism of two groups were measured before and after treatment.Result:Compared with that before operation,the VAS score and ODI score of the two groups were significantly improved 3 days after operation(P<0.05).There were no significant differences in VAS score and ODI score between the two groups(P>0.05).The VAS score and ODI score in the observation group were significantly improved compared with those in the control group,the differences were statistically significant(P<0.05).The BMD of the two groups at 3,6 and 12 months after operation were better than those before operation,but there were no significant differences between the two groups at 3 months after operation and before operation(P>0.05).The BMD of the observation group were significantly higher than those of the control group at 6 and 12 months after operation,the differences were statistically significant(P<0.05).Compared with that before operation,the Cobb angle and vertebral compression rate of the two groups were improved 3 days after operation(P<0.05),but there were no significant differences between the two groups(P>0.05).The compression rate of Cobb angle and vertebral body in the two groups at 3 and 6 months after operation were higher than those at 3 days after operation,the improvement of Cobb angle and vertebral compression rate in the observation group were more significant than those in the control group(P<0.05).The serum

关 键 词：骨康方 经皮穿刺椎体成形术 骨质疏松性椎体压缩骨折 

分 类 号：R687.3[医药卫生—骨科学]