头孢哌酮舒巴坦(舒普深)延长及持续输注在绿脓杆菌肺炎中的疗效对比研究  

Comparative study on the efficacy of cefoperazone sulbactam(supraphan)prolonged infusion in pseudomonas aeruginosa pneumonia

作　　者：李小玲[1] 董利民[1] 廖洁[2] 喻春红 LI Xiao-ling;DONG Li-ming;LIAO Jie;YU Chun-hong(Pingxiang People's Hospital,Pingxiang,Jianxi 337000;Department of Infection,Taizhou Hospital of Traditional Chinese Medicine,Taizhou,Zhejiang 318000)

机构地区：[1]萍乡市人民医院呼吸内科,江西萍乡337000 [2]萍乡市人民医院检验科,江西萍乡337000 [3]浙江省台州市中医院感染科,浙江台州318000

出　　处：《赣南医学院学报》2020年第4期396-399,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：江西省科技厅社会发展项目(2015ZBBG7001)。

摘　　要：目的:探讨头孢哌酮舒巴坦(舒普深)延长分次及持续输注在绿脓杆菌肺炎中的疗效对比。方法:回顾性分析2018年1月-2019年8月我院收治的绿脓杆菌肺炎患者27例,根据药物输注维持时间长短分为3组,A组7例;B组7例,C组13例,A组患者采用持续泵入方式:即微泵泵入头孢哌酮舒巴坦3 g,1次/8 h,每次维持8 h;B组患者采用延长分次方式:即微泵泵入头孢哌酮舒巴坦3 g,1次/8 h,每次维持3 h;C组患者采用常规分次滴注方式:每次滴注头孢哌酮舒巴坦3 g,1次/8 h,每次维持0.5 h。分析并观察3组患者感染控制天数、感染控制率、细菌清除率、28 d全因死亡率及3个月内再入院率。结果:3组患者感染控制天数分别为A组(11.29±6.63)天短于B组(12.86±9.67)天、C组(17.62±17.04)天,差异无统计学意义(P>0.05);绿脓杆菌转阴率A组(58.14%)高于B组(42.86%)、C组(38.46%),差异无统计学意义(P>0.05);3组患者治疗有效率A组(100%)高于B组(71.4%)、C组(92.31%),差异无统计学意义(P>0.05);28天A组无1例病死。结论:采用持续泵入头孢哌酮舒巴坦给药可达到最佳抗菌疗效,且可最大限度减少细菌耐药突变。与分次给药相比,可以缩短绿脓杆菌肺炎患者的感染控制天数,提高绿脓杆菌转阴率,但其统计学差异有待扩大样本量进一步论证。Objective:To compare the efficacy of continuous pumping or extend fractional pumping cefoperazone sulbactan(suprazone)in patients with pseudomonas aeruginosa pneumonia.Methods:27 patients with pseudomonas aeruginosa pneumonia treated in our hospital from January 2018 to August 2019 were retrospectively analyzed,the patients were divided into 3 groups.7 cases in group A.7 cases in group B and 13 cases in group C.Group A were treated by continuous pumping mode:the micro pump pumping cefoperazone sulbactam,3 g,once per 8 h,maintaining 8 h;Group B were treated by extension points:the micro pump pumping cefoperazone sulbactam,3 g,once per8h,maintaining 3 h,Group C were treated by routine drip:each drip cefoperazone sulbactam,3 g,once per8 h,maintaining 0.5 h.The Infection control days,Infection control rate,bacterial clearance rate,mortality in 28 days and Readmission rate within 3 months were analyzed.Results:There was no significant difference in baseline data of gender,age,BMI and APACHE II scores among the 3 groups,the materials had good comparability.The days of infection control in three groups were 11.29±6.63 days,12.86±9.67 days and 17.62±17.04 days respectively,showing no statistical difference(P>0.05).The negative conversion rate of pseudomonas aeruginosa in group A(58.14%)was higher than that in group B(42.86%)and C(38.46%),but there was no statistical difference(P>0.05).The effective rates of patients in the 3 groups were 100%,71.4%and 92.31%respectively,showing no statistical difference.And the rehospitalization rate and mortality also have no statistical difference(P>0.05).Conclusions:Continuous injection and prolonged fractional infusion of cefoperazone sulbactam may shorten the infection control days of patients with pseudomonas aeruginosa pneumonia and improve the negative conversion rate of pseudomonas aeruginosa.

关 键 词：绿脓杆菌肺炎 头孢哌酮舒巴坦 持续泵入 延长分次泵入 常规分次滴注 

分 类 号：R563.1[医药卫生—呼吸系统]