肉桂醛-羟丙基(β)环糊精包合物的处方工艺研究  

Formulation optimization of cinnamaldehyde-hydroxypropyl-β-cyclodextrin inclusion complex

作　　者：孔云 刘黎瑶 熊倩 王庆奎[2] KONG Yun;LIU Li-yao;XIONG Qian;WANG Qing-kui(College of Basic Science,Tianjin Agricultural University,Tianjin 300384,China;Tianjin Key Lab of Aquatic Ecology and Aquaculture,Tianjin Agricultural University,Tianjin 300384,China)

机构地区：[1]天津农学院基础科学学院,天津300384 [2]天津农学院天津市水产生态及养殖重点实验室,天津300384

出　　处：《天津农学院学报》2020年第1期70-75,共6页Journal of Tianjin Agricultural University

基　　金：天津市教委科研计划项目(2017KJ181);天津市水产产业技术体系创新团队项目(ITTFRS2017004);国家自然科学基金面上项目(31170442)。

摘　　要：本研究旨在利用羟丙基(β)环糊精包合技术,提高肉桂醛原料药的稳定性并增加其水溶性。通过溶剂-旋转蒸发法,以包合率(CE)为筛选指标,通过单因素筛选以及正交设计,筛选得到制备肉桂醛-羟丙基(β)环糊精包合物的最佳处方。优选包合条件下,肉桂醛与羟丙基(β)环糊精的最佳质量比例为1∶15;质量浓度比例为1∶8;超声包合时间为15 min。使用该优选处方工艺,在极短的包合时间内即可使肉桂醛-羟丙基(β)环糊精包合率达到90%以上,4℃条件下可稳定保存3个月。该研究为肉桂醛-羟丙基(β)环糊精包合物的后期应用奠定了物质基础。This study was designed to increase stability and hydrophilicity of cinnamaldehyde through hydroxypropyl-β-cyclodextrin inclusion technology.In this study,associative efficiency(CE)was set as screening parameter and optimal formulation of cinnamaldehyde-hydroxypropyl-β-cyclodextrin inclusion complex was obtained using solvent evaporation method based on single factor screening and orthogonal design.Under the selected formulation,mass ratio of cinnamaldehyde to hydroxypropyl-β-cyclodextrin was 1∶15 and composite time was 15 minutes under supersonic condition with mass concentration ratio of 1∶8.For the selected formulation,CE of inclusion complex could reach 90%and storage stability remained in 3 months under 4℃,which provides basis for practical application.

关 键 词：肉桂醛 羟丙基(β)环糊精包合物 正交设计 处方筛选 

分 类 号：P641.131[天文地球—地质矿产勘探] S152.72[天文地球—地质学]