烟酰胺乳膏剂的制备处方研究  

Study on ointment formulation design of nicotinamide

作　　者：洪静 刘黎瑶 王庆奎[2] HONG Jing;LIU Li-yao;WANG Qing-kui(College of Basic Science,Tianjin Agricultural University,Tianjin 300384,China;Tianjin Key Lab of Aquatic Ecology and Aquaculture,Tianjin Agricultural University,Tianjin 300384,China)

机构地区：[1]天津农学院基础科学学院,天津300384 [2]天津农学院天津市水产生态及养殖重点实验室,天津300384

出　　处：《天津农学院学报》2020年第1期76-81,共6页Journal of Tianjin Agricultural University

基　　金：天津市教委科研计划项目(2017KJ181);天津市水产产业技术体系创新团队项目(ITTFRS2017004);国家自然科学基金面上项目(31170442)。

摘　　要：烟酰胺是一种吡啶衍生物,经皮给药后可发挥抑制黑色素转移、抗自由基氧化,抗炎和增强皮肤屏障等多种作用。但其酰胺结构易被氧化产生烟酸,造成皮肤刺激性,引发皮肤不良反应。本研究通过水相乳化法将烟酰胺制备成油包水(W/O)型乳膏剂,增加烟酰胺的稳定性及用药便捷性,并以外观均一性、涂布延展性、离心稳定性以及耐寒耐热性的综合评分作为考察指标,对油相/水相比例、乳化剂以及辅助乳化剂的用量进行单因素影响试验及正交设计,筛选得到制备烟酰胺乳膏剂的最佳处方。优选处方下,油相/水相的质量比例为6∶4,乳化剂Span-60与辅助乳化剂Tween-80的质量分数分别为1%及0.5%。根据优选处方制备得到的烟酰胺乳膏剂稳定性良好,常温(25℃)下可稳定保存3个月。该研究为其后期进一步应用奠定了物质基础。Nicotinamide is a kind of pyridine derivative,which has various pharmacological effects such as inhibition of melanic transmission,anti-free radical,anti-aging,anti-inflammatory and enhancement of skin barrier after transdermal administration.However,due to its structure of amide,nicotinamide could be oxidized to nicotinic acid,which could cause dermal irritation and side effects.Thus,water-in-oil(W/O)ointment was prepared to enhance stability and compliance of nicotinamide.In this investigation,comprehensive scoring of homogeneity,extensibility,centrifugal stability and cold/heat resistance was set as the evaluation indicator to obtain the optimal proportion of oil phase,emulsifier and coemulsifier through single-factor experiment and orthogonal screening.under the optimal formulation.Span-60 and Tween-80 were used as emulsifier and coemulsifier respectively with the mass percentage of 1%,and the weight ratio of oil to water was 6∶4.Under the selected formulation,storage stability of ointment remained in 3 months under 25℃,which provides the basis for practical application.

关 键 词：烟酰胺 乳膏剂 单因素影响试验 正交设计 处方筛选 

分 类 号：P641.131[天文地球—地质矿产勘探] S152.72[天文地球—地质学]