一种基于萘酰亚胺神经介质模拟物荧光增强型探针  

A naphthalimide-based fluorescence-enhanced probe for nerve agent mimics

作　　者：赵磊 陈康 程探宇 ZHAO Lei;CHEN Kang;CHENG Tanyu(College of Chemistry and Materials Science,Shanghai Normal University,Shanghai 200234,China)

机构地区：[1]上海师范大学化学与材料科学学院,上海200234

出　　处：《上海师范大学学报（自然科学版）》2020年第2期184-190,共7页Journal of Shanghai Normal University(Natural Sciences)

基　　金：国家自然科学基金(21872095)。

摘　　要：神经毒剂,如沙林、梭曼和塔崩等都是剧毒的有机磷化合物,可以用作化学武器,主要是抑制乙酰胆碱酶的活性,进而引起神经系统的紊乱,所以快速方便地检测此类化合物具有重要的意义.设计并合成了一种以萘酰亚胺为荧光团、肼基作为活性基团的快速响应荧光探针(PND),该探针可用于检测神经毒剂模拟物:氯磷酸二乙酯(DCP)和氰基磷酸二乙酯(DCNP),而且表现出了高选择性和高灵敏度.Neurotoxic agents,such as sarin,soman and tauben,are highly toxic organophosphorus compounds,which can be used as chemical weapons.These compounds mainly inhibit the activity of acetylcholine enzymes,which in turn cause nervous system disorders.Thus,it is greatly important to quickly and conveniently detect such compounds.Herein,a fluorescent probe(PND)based on naphthalimide and hydrazine group was developed,which displayed high selectivity and sensitivity for nerve agent mimicsdiethyl chlorophosphate(DCP)and diethyl cyanophosphonate(DCNP).

关 键 词：荧光探针 萘酰亚胺 水合肼 神经性毒剂 

分 类 号：O657.34[理学—分析化学]