聚羟基脂肪酸酯/海藻酸钠纳米纤维的制备及其性能  

Preparation and properties of polyhydroxy fatty acid ester/sodium alginate composite electrospun nanofibers

作　　者：孙范忱 郭静 于跃 张森 SUN Fanchen;GUO Jing;YU Yue;ZHANG Sen(School of Textile and Material Engineering,Dalian Polytechnic University,Dalian,Liaoning 116034,China;Liaoning Provincial Engineering Research Center of Functional Fiber and Its Composite Materials,Dalian,Liaoning 116034,China)

机构地区：[1]大连工业大学纺织与材料工程学院,辽宁大连116034 [2]辽宁省功能纤维及复合材料工程技术中心,辽宁大连116034

出　　处：《纺织学报》2020年第5期15-19,29,共6页Journal of Textile Research

基　　金：国家自然科学基金项目(51773024,51373027);辽宁省科技创新团队项目(LT2017017)。

摘　　要：针对聚羟基脂肪酸酯(P(3HB-co-4HB))和海藻酸钠(SA)常规情况下难共溶的问题,以P(3HB-co-4HB)为原料,SA为改性剂,三氯甲烷/水为溶剂,烷基糖苷(APG)为乳化剂,通过共混利用静电纺丝法制备了P(3HB-co-4HB)/SA纳米纤维膜。借助红外光谱仪、差示扫描量热仪、扫描电子显微镜表征P(3HB-co-4HB)/SA静电纺纳米纤维的分子间作用力、热性能和形貌;利用细胞毒性和细胞共培养测试表征了P(3HB-co-4HB)/SA纳米纤维的生物相容性。结果表明:P(3HB-co-4HB)/SA复合材料的玻璃化转变温度发生改变,当添加SA质量分数为6%时,静电纺纳米纤维具有均一的形貌,纳米纤维的平均直径为500 nm,孔隙率为74%,细胞毒性等级为0级,P(3HB-co-4HB)和SA具有良好的生物相容性。Aiming at the problem that polyhydroxy fatty acid ester( P( 3 HB-co-4 HB)) and sodium alginate( SA) are difficult to co-solve under normal circumstances,a P( 3 HB-co-4 HB)/SA nanofiber membrane were prepared using P( 3 HB-co-4 HB) as raw material,SA as modifier,chloroform/water as solvent,alkyl glycoside as emulsifier. The intermolecular forces,thermal properties and morphology of P( 3 HB-co-4 HB)/SA electrospinning nanofibers were characterized by infrared spectrometer,differential scanning calorimeter,and scanning electron microscope. The biocompatibility of P( 3 HB-co-4 HB)/SA nanofibers was characterized by cytotoxicity test and cell co-culture. The results show that the formation of the P( 3 HB-co-4 HB)/SA composite material caused changes in glass transition temperature. When the mass fraction of SA is 6%,the electrospinning nanofibers have a uniform morphology,and the average diameter of the nanofibers is 500 nm. It demonstrates a porosity of 74% and the grade 0 cytotoxicity,and the P( 3 HB-co-4 HB)) and SA has good biocompatibility.

关 键 词：聚羟基脂肪酸酯 海藻酸钠 纳米纤维 生物相容性 静电纺丝 

分 类 号：TB332[一般工业技术—材料科学与工程]