改进Duff反应合成5-硝基水杨醛  

Improves the Method of the Duff Reaction to Prepare 5-nitrosaicylaldehyde

作　　者：巩冰倩 张文雯[1] 翁智兵 王聿鹏 叶爱英[1] Gong Bingqian;Zhang Wenwen;Weng Zhibing;Wang Yupeng;Ye Aiying(Department of Chemical and Pharmaceutical Engineering,Changzhou Institute of Engineering Technology,Changzhou 213164,China)

机构地区：[1]常州工程职业技术学院化工与制药工程学院,江苏常州218164

出　　处：《广东化工》2020年第9期85-86,共2页Guangdong Chemical Industry

摘　　要：用对甲苯磺酸改进Duff反应合成了5-硝基水杨酸,探讨了催化剂用量、反应物用量、反应时间、反应温度对5-硝基水杨酸收率的影响。结果表明较佳反应条件是:在对硝基苯酚为14g的情况下,对甲苯磺酸的用量为26g,n(六亚甲基四胺)︰n(对硝基苯酚)=1.5︰1,反应时间为2.0 h,反应温度70℃,5-硝基水杨醛的产率可达86.5%。Synthesis of 5-nitrosaicylaldehyde was studied by the improved method of the Duff reaction with p-toluenesulfonic acid.The effects of catalyst dosage,reactant dosage,reaction time and temperature on the yield of 5-nitrosaicylaldehyde were investigated.The studies showed that the optimum conditions of the reaction were the amount of p-nitrophenol 14 g,p-toluenesulfonic acid 26 g,the mole ratio of hexamethylene tetramine to p-nitrophenol was 1.5︰1,the reaction time was about 2.0 hours and the reaction temperature was about 70℃.Under the optimum conditions,the highest yield of 5-nitrosaicylaldehyde reached 86.5%.

关 键 词：5-硝基水杨醛 Duff反应 对甲苯磺酸 

分 类 号：TQ42[化学工程]