黄芪注射液辅助治疗支气管哮喘急性发作及对相关因素的作用  

Effects of Astragalus Injections in adjuvant treatment on acute attack of bronchial asthma and on related factors

作　　者：周拓 许东风[1] 徐慧[1] 丁锋[1] ZHOU Tuo;XU Dongfeng;XU Hui;DING Feng(Department of Respiratory and Intensive Care Medicine,the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,China)

机构地区：[1]南阳医学高等专科学校第一附属医院呼吸与危重症医学科,南阳473000

出　　处：《西北药学杂志》2020年第3期435-439,共5页Northwest Pharmaceutical Journal

摘　　要：目的探讨使用糖皮质激素治疗支气管哮喘(BA)急性发作时辅助应用黄芪注射液的临床疗效。方法将入选的90例BA急性发作期患者随机分为对照组和联合组。对照组予以布地奈德气雾剂治疗,联合组在对照组治疗的基础上辅以静脉滴注黄芪注射液,2组均治疗14 d。分别测量治疗前和治疗14 d后患者第1 s用力呼气容积(FEV 1)、用力肺活量(FVC)、呼气峰流速(PEF)和气道反应性指标[FEV 1较对照值下降20%的最低累积剂量(PD20-FEV 1)],测定患者外周血中T辅助细胞1(Th1)与T辅助细胞2(Th2)比例以及血清中白细胞介素2(IL-2)、白细胞介素4(IL-4)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)和干扰素γ(IFN-γ)的水平。比较2组治疗后的疗效。结果治疗14 d后,联合组的肺功能指标(FEV 1、FVC和PEF)和PD20-FEV 1均明显高于对照组(P<0.05);联合组较对照组Th1增加,Th2减少,T辅助细胞1/T辅助细胞2(Th1/Th2)升高(P<0.05);联合组有效率(95.65%)明显高于对照组(79.55%)(P<0.05)。结论黄芪注射液辅助布地奈德气雾剂治疗BA急性发作能有效提高疗效,改善肺功能,降低气道反应性和炎性因子水平,改善哮喘患者的免疫失衡。Objective To explore the clinical curative effect of glucocorticoid assisted by Astragalus Injections on acute attack of bronchial asthma(BA).Methods 90 patients with acute attack of BA were randomly divided into control group and combination group.The control group was given budesonide aerosol.On this basis,the combination group was supplemented with intravenous infusion of Astragalus Injections.The both groups were treated for 14 d.Before and at 14 d after treatment,forced expiratory volume in one second(FEV 1),forced vital capacity(FVC),peak expiratory flow(PEF)and airway reactivity index[the lowest cumulative dose of FEV 1 decreased by 20%compared with the control value(PD20-FEV 1)]were measured.The ratios of T helper cell 1(Th1)and T helper cell 2(Th2)cells in peripheral blood,and levels of serum interleukin 2(IL-2),interleukin 4(IL-4),interleukin 6(IL-6),tumor necrosis factorα(TNF-α)and interferonγ(IFN-γ)were determined.The curative effect after treatment was compared between the 2 groups.Results At 14 d after treatment,FEV 1,FVC,PEF and PD20-FEV 1 of the combination group were significantly higher than those of the control group(P<0.05).Compared with the control group,Th1 was increased in combination group,while Th2 was decreased,and Th1/Th2 was increased(P<0.05).The response rate in combination group was significantly higher than that in control group(95.65%vs 79.55%)(P<0.05).Conclusion Budesonide aerosol assisted by Astragalus Injections in the treatment of acute attack of BA can effectively improve the curative effect and lung function,reduce the airway responsiveness and levels of inflammatory factors,and improve the immune imbalance in asthma patients.

关 键 词：黄芪注射液 布地奈德 支气管哮喘 急性发作期 

分 类 号：R974[医药卫生—药品]