有机催化丙二酸酯与β-硝基烯烃的不对称Michael加成反应  

Organocatalyzed asymmetric Michael reaction of malonates withβ-nitroolefins

作　　者：王黎明 李冉彤 吴淑宝 金瑛 WANG Li-ming;LI Ran-tong;WU Shu-bao;JIN Ying(Department of Pharmacy,Jilin Medical University,Jilin 132013,China)

机构地区：[1]吉林医药学院药学院,吉林吉林132013

出　　处：《化学研究与应用》2020年第5期746-751,共6页Chemical Research and Application

基　　金：国家自然科学基金项目(21102055)资助;吉林省自然科学基金项目(20190201077JC)资助;吉林省大学生创新创业训练计划项目(201913706058)资助。

摘　　要：将金鸡纳生物碱衍生物用于催化丙二酸酯和β-硝基芳基乙烯的不对称Michael加成反应。考察溶剂、温度及催化剂用量对反应催化性能的影响。结果表明,最佳催化条件为5 mol%催化剂1e,甲苯为溶剂,0℃反应。得到了86~93%的化学产率和最高达99%ee的对映选择性。Cinchona alkaloid derivatives as organocatalysts were applied in asymmetric Michael addition of malonates withβ-nitroolefins.The effect of solvent,temperature and catalyst loading amount were investigated.The optimized conditions were determined with toluene as the solvent with 5 mol%loading of catalyst 1 e at 0℃.The desired products were obtained in 86~93%yield with up to 99%ee.

关 键 词：金鸡纳生物碱衍生物 有机催化 不对称MICHAEL加成反应 丙二酸酯 β-硝基芳基乙烯 

分 类 号：O621.3[理学—有机化学]