影响根尖牙乳头干细胞成牙本质方向分化的因素  

Factors influencing differentiation of stem cells from the apical papilla into odontoblasts

作　　者：王雯虹 李言君[1] 崔彩云 Wang Wenhong;Li Yanjun;Cui Caiyun(Department of Oral Medicine,Affiliated Hospital of Binzhou Medical University,Binzhou 256600,Shandong Province,China)

机构地区：[1]滨州医学院附属医院口腔内科,山东省滨州市256600

出　　处：《中国组织工程研究》2020年第31期5071-5078,共8页Chinese Journal of Tissue Engineering Research

基　　金：山东省自然科学基金(ZR2019PH083),项目负责人:崔彩云;山东省医药卫生科技发展计划项目(2017WS552),项目负责人:崔彩云。

摘　　要：背景:根尖牙乳头干细胞是一类牙源性间充质干细胞,在特定诱导因素作用下可分化为成牙本质细胞,形成牙根部牙本质。修复和再生牙髓牙本质复合体是临床治疗牙髓及根尖周病的新策略,尤其是年轻恒牙的保留,因此定向诱导根尖牙乳头干细胞成牙本质方向分化具有重要意义。目的:综述影响根尖牙乳头干细胞成牙本质方向分化的因素,以期为年轻恒牙牙根发育及临床其他领域应用提供研究基础。方法:应用计算机在PubMed数据库、维普数据库、万方数据库及中国期刊全文数据库检索2013年1月至2019年12月相关文献,以“SCAP,odontogenic differentiation”为英文检索词,以“根尖牙乳头干细胞,成牙本质细胞分化”为中文检索词,最终对38篇文献进行归纳总结,其余18篇文献进一步解释说明文章内容。结果与结论:文章系统性回顾了根尖牙乳头干细胞在不同诱导因素作用下通过相关信号通路传导参与根尖牙乳头干细胞向成牙本质细胞定向诱导,例如细胞因子、基因转染、生物活性材料及支架、化学因素、物理因素等。探寻诱导根尖牙乳头干细胞成牙本质方向分化的理想条件,明确其作用效果和作用机制是临床治疗牙髓病、根尖周病及牙髓牙本质复合体组织工程研究的关键问题。BACKGROUND:Stem cells from the apical papilla are a kind of odontogenic mesenchymal stem cells that can differentiate into odontoblasts under the action of special inducing factors,further forming the root dentin.Restoration and regeneration of pulp-dentin complex is a new clinical strategy for the treatment of pulp and periapical diseases,especially for the retention of young permanent teeth.Directional induction of stem cells from the apical papilla into odontoblasts has gradually become a hot topic in endodontology.OBJECTIVE:To review the factors related to the differentiation of stem cells from the apical papilla into dontoblasts,in order to provide the research basis for the root development of young permanent teeth and other clinical applications.METHODS:PubMed,VIP,WanFang and China Journal Full-Text databases were searched for relevant literatures published from January 2013 to December 2019 using the keywords of“SCAP,odontogenic differentiation”in English and Chinese,respectively.Finally,38 articles were retrieved and summarized,and the remaining 18 articles were further explained of the literature content.RESULTS AND CONCLUSION:We systematically reviewed the odontogenic differentiation of stem cells from the apical papilla via relevant signaling pathways under specific induction factors,including cytokines,gene transfection,bioactive materials and scaffolds,chemical factors,and physical factors.Seeking for the ideal conditions for the odontogenic differentiation of stem cells from the apical papilla as well as relevant effects and mechanism is very important for the treatment of pulp and periapical disease and for the study on pulp-dentin complex in tissue engineering field.

关 键 词：根尖牙乳头干细胞 成牙本质细胞 细胞分化 细胞因子 基因转染 生物陶瓷材料 支架材料 信号通路 

分 类 号：R459.9[医药卫生—治疗学] R394.2[医药卫生—临床医学]