表面增强拉曼光谱技术检测新型冠状病毒刺突蛋白  

Detection of spike protein of SARS-CoV-2 by surface enhanced Raman spectroscopy

作　　者：黄景林[1] 周民杰[1] 乐玮[1] 陈果[1] 倪爽 牛高[1] 李赜宇[1] 赵宗清[1] 何智兵[1] 李波[1] 赵松楠[1] 张保汉[1] 杜凯[1] Huang Jinglin;Zhou Minjie;Le Wei;Chen Guo;Ni Shuang;Niu Gao;Li Zeyu;Zhao Zongqing;He Zhibing;Li Bo;Zhao Songnan;Zhang Baohan;Du Kai(Research Center of Laser Fusion,CAEP,P.O.Box 919-988,Mianyang 621900,China)

机构地区：[1]中国工程物理研究院激光聚变研究中心,四川绵阳621900

出　　处：《强激光与粒子束》2020年第6期137-138,共2页High Power Laser and Particle Beams

摘　　要：开发具有高灵敏度、高准确性的新型冠状病毒(SARS-CoV-2)快速检测技术对疫情防控具有重要作用。本文利用表面增强拉曼光谱(SERS)技术对人体唾液中的痕量SARS-CoV-2病毒刺突蛋白(S蛋白)进行了检测。结果表明,含S蛋白的唾液样本与原始唾液样本的拉曼光谱具有显著区别,含S蛋白的唾液样本谱图中可清晰观察到属于S蛋白的拉曼谱线。该结果为后续SERS技术在SARS-CoV-2病毒快速检测方面的应用奠定了坚实基础。The development of rapid detection technique with high sensitivity and high veracity for SARS-CoV-2 is of great importance for the prevention and control of epidemic.In this work,the trace spike protein(S protein)of SARS-CoV-2 in human saliva was detected by surface enhanced Raman spectroscopy(SERS)technique.Significant differences can be found between the Raman spectra of the S protein stained saliva sample and the primitive saliva sample.These results will lay the foundation for the future rapid detection of SARS-CoV-2 by SERS technique.

关 键 词：表面增强拉曼光谱 新型冠状病毒 刺突蛋白 快速检测 

分 类 号：O433.4[机械工程—光学工程]