连续流微反应器中2-氨基-3-硝基苯甲酸甲酯的合成  

Synthesis of Methyl 2-amino-3-nitrobenzoate in a Continuous Flow Microreactor

作　　者：王源 肖燕[1] 王俊峰 周英雷 钱捷[1] 夏春年[1] WANG Yuan;XIAO Yan;WANG Jun-feng;ZHOU Ying-lei;QIAN Jie;XIA Chun-nian(College of Pharmacy,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China;Zhejiang Juxian Pharmaceutical Technology Co.,Ltd.,Taizhou,Zhejiang 317016,China)

机构地区：[1]浙江工业大学药学院,浙江杭州310014 [2]浙江聚贤医药科技有限公司,浙江台州317016

出　　处：《浙江化工》2020年第5期14-18,51,共6页Zhejiang Chemical Industry

基　　金：浙江工业大学横向(H1160190007)。

摘　　要：使用连续流微反应器技术对坎地沙坦酯重要中间体2-氨基-3-硝基苯甲酸甲酯进行连续化工艺改造。以邻苯二甲酸酐为原料,在微反应器中进行Hoffmann降解反应、硝化反应,再使用浓硫酸重排的三步连续流反应制得2-氨基-3-硝基苯甲酸甲酯。对每步反应进行了优化,确定了反应的最佳条件。Continuous flow microreactor technology was used to modify the continuous process of 2-amino-3-nitrobenzoate, an important intermediate of candesartan ester. Using phthalic anhydride as raw material, 2-amino-3-nitrobenzoic acid methyl ester was prepared by Hoffmann degradation and nitrification in a microreactor, followed by three-step continuous flow reaction of concentrated sulfuric acid rearrangement. Each step of the reaction was optimized and the optimum conditions were determined.

关 键 词：微通道反应器 2-氨基-3-硝基苯甲酸甲酯 连续流 

分 类 号：TQ463[化学工程—制药化工]