白细胞免疫球蛋白活化受体3与多囊卵巢综合征患者病情及临床预后的关系  

Relationship between leukocyte immunoglobulin activator receptor 3 and the condition and clinical prognosis of patients with polycystic ovary syndrome

作　　者：李书艳 徐定英 曹文丽 LI Shu-yan;XU Ding-ying;CAO Wen-li(Zhoushan Maternal and Child Health-care Hospital,Zhoushan,Zhejiang 316000,China)

机构地区：[1]舟山市妇幼保健院,浙江舟山316000

出　　处：《中国卫生检验杂志》2020年第9期1107-1109,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨白细胞免疫球蛋白活化受体3基因多态性与多囊卵巢综合征(PCOS)患者病情及临床预后的关系。方法选取本院2016年11月-2017年11月就诊的120例多囊卵巢综合征患者作为PCOS组,根据鹿特丹及2012年依据NIH推荐标准分为A、B、C、D型,并以同期健康体检的30例正常成年女性作为对照组,采用实时定量PCR法检测患者外周血中白细胞免疫球蛋白活化受体3基因型和mRNA水,对比不同基因型和不同病情患者LILRA3 mRNA水平。结果 PCOS组C/C基因型分布率为48. 3%,明显高于对照组的10. 0%,而随着PCOS病情加重基因型为C/C患者的分布率逐渐升高,D型患者为63. 4%,明显高于A、B、C型患者,PCOS组患者各基因型患者LILRA3 mRNA水平均明显高于对照组患者,而C/C的患者LILRA3 mRNA水平明显高于其他同组的各基因型的患者,NIH分型为D型、C/C、LILRA3 mRNA是不孕不育的独立危险因素(P <0. 05)。结论多囊卵巢综合征患者LILRA3基因型和mRNA表达与患者病情及预后密切相关。Objective To investigate the relationship between leukocyte immunoglobulin-activated receptor 3 gene polymorphism and the disease severity and clinical prognosis of patients with polycystic ovary syndrome(PCOS).Methods A total of120 patients with polycystic ovary syndrome(PCOS)from November 2016 to November 2017 in our hospital were selected as the observation group and divided into A,B,C and D types according to the NIH recommendation standard in Rotterdam,2012.Thirty normal adult women who underwent physical examination at the same time were selected as control group.The white blood cells in peripheral blood of patients were detected by real-time quantitative PCR.Immunoglobulin-activated receptor3 genotypes and mRNA water were used to compare LILR A3 mRNA levels in patients with different genotypes and conditions.Results The distribution rate of C/C genotype in PCOS group was 48.3%higher than that in control group(10.0%).With the aggravation of PCOS,the distribution rate of genotype C/C increased gradually.63.4%of patients with genotype D was significantly higher than that of patients with A,B and C.The LILRA3 mRNA level in genotype patients of PCOS group was significantly higher than that of control group.ILRA3 mRNA level was significantly higher than that of other genotypes in the same group.NIH genotype D,C/C,and mRNA were independent risk factors for infertility.Conclusion The levels of ILRA3 genotype and mRNA in patients with polycystic ovary syndrome is closely related to their condition and prognosis.

关 键 词：多囊卵巢综合征 白细胞免疫球蛋白活化受体3 病情 预后 

分 类 号：R711.75[医药卫生—妇产科学]