痛风及高尿酸患者易患尿路结石机制  

Mechanisms of susceptibilities to urolithiasis in patients with gout and hyperuricemia

作　　者：曹宇 张昀[1] 曾学军[1] CAO Yu;ZHANG Yun;ZENG Xue-jun(Department of General Internal Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院普通内科,北京100730

出　　处：《中华临床免疫和变态反应杂志》2020年第2期150-154,共5页Chinese Journal of Allergy & Clinical Immunology

基　　金：首都卫生发展科研专项(2018-1-4012)。

摘　　要：痛风和高尿酸血症患者是尿路结石的高发人群。现有的结石治疗方法难以解决结石反复复发的难题,为充分改善患者生活质量,在结石形成之前对可控的危险因素进行控制十分必要。尿酸和草酸钙结石是最常见的结石类型,痛风和高尿酸血症患者尿pH、尿酸排泄量及尿量对这两种结石的形成起到复杂的影响,本文对痛风及高尿酸血症患者易患结石的机制进行综述,以指导临床诊治,减少结石的形成风险。Gout and hyperuricemia is associated with an increased risk of urolithiasis.Current treatment modalities for urolithiasis could not fully improve patients'quality of life unless stone recurrence is addressed.Therefore,identification and management of controllable risk factors is necessary.Urine pH,uric acid excretion,and urine volume play complicated roles in the formation of uric acid and calcium oxalate stones,which are the most common stone types.Accordingly,the mechanisms of susceptibilities to urolithiasis are reviewed in patients with gout and hyperuricemia,to guide clinical management and risk reduction.

关 键 词：尿路结石 胰岛素抵抗 尿PH 尿酸排泄 

分 类 号：R589.7[医药卫生—内分泌]