Arsenic species in electronic cigarettes:Determination and potential health risk  

作　　者：Qingqing Liu Chengzhi Huang XChris Le 

机构地区：[1]Chongqing Key Laboratory of Biomedical Analysis(Southwest University),Chongqing Science&Technology Commission,College of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715,China [2]College of Resources and Environment,Southwest University,Chongqing,400715,China [3]Key Laboratory of Luminescent and Real-Time Analytical System,Chongqing Science and Technology Bureau,College of Pharmaceutical Sciences,Southwest University,Chongqing 400715,China [4]Department of Laboratory Medicine and Pathology,Faculty of Medicine and Dentistry,University of Alberta,10102 Clinical Sciences Building,Edmonton,Alberta T6G 2G3,Canada

出　　处：《Journal of Environmental Sciences》2020年第5期168-176,共9页环境科学学报（英文版）

基　　金：supported by National Natural Science Foundation of China(Nos.21535006,21906130);Southwest University Postdoctoral Science Foundation(Nos.5330600027,5330600094);the Natural Sciences and Engineering Research Council of Canada;the Canadian Institutes of Health Research,Alberta Innovates;Alberta Health

摘　　要：Human exposure to contaminants from electronic cigarettes(e-cigarettes)and the associated health effects are poorly understood.There has been no report on the speciation of arsenic in e-liquid(solution used for e-cigarettes)and aerosols.We report here determination of arsenic species in e-liquids and aerosols generated from vaping the e-liquid.Seventeen e-liquid samples of major brands,purchased from local and online stores in Canada and China,were analyzed for arsenic species using high-performance liquid chromatography and inductively coupled plasma mass spectrometry.Aerosols condensed from vaping the eliquids were also analyzed and compared for arsenic species.Six arsenic species were detected,including inorganic arsenate(iAsⅤ),arsenite(iAsⅢ),monomethylarsonic acid(MMA),and three new arsenic species not reported previously.In e-liquids,iAsⅢwas detected in 59%,iAsⅤin 94%,and MMA in 47%of the samples.In the condensate of aerosols from vaping the e-liquids,iAsⅢwas detected in 100%,iAsv in 88%,and MMA in 13%of the samples.Inorganic arsenic species were predominant in e-liquids and aerosols of e-cigarettes.The concentration of iAsⅢin the condensate of aerosols(median 3.27μg/kg)was significantly higher than that in the e-liquid(median 1.08μg/kg)samples.The concentration of inorganic arsenic in the vaping air was approximately 3.4μg/m3,which approaches to the permissible exposure limit(10μg/m3)set by the United States Occupational Safety and Health Administration(OSHA).According to the Environmental Protection Agency’s unit risk factor(4.3×10-3 perμg/m3)for inhalation exposure to inorganic arsenic in the air,the estimated excess lung cancer risk from lifetime exposure to inorganic arsenic in the ecigarette vaping air(3.4μg/m3),assuming e-cigarette vaping at 1%of the time,is as high as1.5×10-4.These results raise health concerns over the exposure to arsenic from electronic cigarettes.

关 键 词：Electronic cigarettes E-liquid E-cigarette aerosol Arsenic speciation Inhalation exposure METALS Lung cancer risk 

分 类 号：TS458[农业科学—烟草工业]