新型冠状病毒肺炎潜在药物和疗法的作用机制及治疗现状  

The action mechanism and treatment status of potential drugs and therapies for coronavirus disease 2019

作　　者：东静玉 宋佳静 孙燕[1] 李治[1] DONG Jingyu;SONG Jiajing;SUN Yan;LI Zhi(School of Life Sciences,Shaanxi Normal University,Xi′an 710119,Shaanxi,China)

机构地区：[1]陕西师范大学生命科学学院,陕西西安710119

出　　处：《陕西师范大学学报（自然科学版）》2020年第3期7-17,共11页Journal of Shaanxi Normal University：Natural Science Edition

基　　金：国家自然科学基金(31670163)。

摘　　要：为了尽快解决新型冠状病毒肺炎(COVID-19)临床无特效药物的现状,“老药新用”成为国内外相关研究机构采取的主要抗疫策略之一。本文在比较COVID-19病原体SARS-CoV-2与SARS-CoV及其他相关RNA病毒的异同点、分析其特点及侵染机制的基础上,对当前已报道的有望治疗COVID-19的潜在药物和治疗方法进行归纳总结,主要包括以病毒为靶点的药物(阿比朵尔、格瑞弗森、利巴韦林、瑞德西韦、法匹拉韦、达芦那韦、克力芝、双硫仑)、以宿主为靶点的药物(干扰素、恢复期血浆制品、氯喹/磷酸氯喹)、机制复杂的中草药以及干细胞疗法和RNAi疗法,重点阐释相关药物及疗法的具体作用机制及其应用于COVID-19的治疗现状,以期为COVID-19有效药物的研发和治疗提供一定的参考。With the global prevalence of coronavirus disease 2019(COVID-19),the development of anti-COVID-19 drugs is becoming more and more urgent.As there are no specific drugs available for COVID-19 currently,“new use of old drugs”has become one of the main anti-epidemic strategies adopted by many research institutions at home and abroad.On the basis of analyzing COVID-19 characteristics,infection mechanism and the similarities of SARS-CoV-2(the pathogen of COVID-19)with SARS-CoV and other related RNA viruses,the antiviral drugs and therapies which may be useful to treat COVID-19 were analyzed and summarized,including virus-targeted drugs,host-targeted drugs,herbal medicine,stem cell therapy and RNAi therapy.The specific action mechanism of relevant drugs and therapies as well as their current application status in the treatment of COVID-19 were mainly elucidated,so as to provide certain reference for the development of effective drugs and treatment methods for COVID-19.

关 键 词：新型冠状病毒肺炎 SARS-CoV-2 药物作用机理 病毒靶点 宿主靶点 

分 类 号：R965[医药卫生—药理学]