铜催化N′-芳基苯磺酰肼的N′-芳基化反应  

Copper-catalyzed N′-arylation of N′-aryl Benzenesulfonohydrazide

作　　者：叶秋香 任淼锋 胡馨[2] 刘晋彪[1] YE Qiu-xiang;REN Miao-feng;HU Xin;LIU Jin-biao(Department of Chemistry,Jiangxi University of Science and Technology,Ganzhou 341000,China;School of Pharmaeutical Sciences,Gannan Medical University,Ganzhou 341000,China)

机构地区：[1]江西理工大学化学系,江西赣州341000 [2]赣南医学院药学院,江西赣州341000

出　　处：《合成化学》2020年第5期431-434,共4页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21762018,21961014);江西省教育厅科技项目(151357);江西省自然科学基金资助项目(20192BCBL23009)。

摘　　要：以N′-芳基苯磺酰肼作为芳基化试剂,在铜催化下,实现N′-芳基苯磺酰肼的自身N-芳基化反应。该反应以5 mol%的醋酸铜为催化剂,三乙胺为碱,甲醇为溶剂,常温下N′-芳基苯磺酰肼反应4~8 h,产率最高可达88%。产物结构经^1H NMR,^13C NMR和HR-MS(ESI)表征。Copper-catalyzed N′-arylation of N′-aryl benzenesulfonohydrazine under mild conditions has been reported in this paper.A mixture of N′-tosyl arylhydrazine(0.3 mmol),Cu(OAc)2·H2O(5 mol%),and Et3N(0.3 mmol)was stirred at room temperature in methanol(2 mL)for 4~8 h.The highest yield is up to 88%.The structures were characterized by ^1H NMR,^13C NMR and HR-MS(ESI).

关 键 词：铜催化 芳基化 磺酰肼 醋酸铜 三乙胺 合成 

分 类 号：O631.3[理学—高分子化学]