新型1,2,4-三取代-1,2,3-三氮唑盐的合成  

Synthesis of A Novel 1,2,4-Trisubstituted-1,2,3-triazole Salt

作　　者：敖慧龙 张磊[1] 袁克萌 王飞军 石晓濛 AO Hui-long;ZHANG Lei;YUAN Ke-meng;WANG Fei-jun;SHI Xiao-meng(College of Chemistry and Molecular Engineering,East China University of Science And Technology,Shanghai 200237,China)

机构地区：[1]华东理工大学化学与分子工程学院,上海200237

出　　处：《合成化学》2020年第4期291-295,共5页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金面上项目(21372075);浦江人才计划(16PJD017)。

摘　　要：以邻溴苄醇(1)和水杨醛(2)为原料,经5步反应合成了一种分子内同时具有羟基和1,2,3-三氮唑环的新型类卡宾前体盐中间化合物(7),在三氟甲磺酸酐的催化下,分子内六元环化反应得到一种新型的1,2,4-三取代-1,2,3-三氮唑并三环体系类卡宾前体盐(8),其结构经1H NMR,13C NMR和MS(ESI)表征。A novel intermediate compounds(7)of the carbin precurssor salt that contain hydroxyl and 1,2,3-triazole intramolecularly was synthesized by o-bromo-benzol(1)and salicylaldehyde(2)through 5 steps.Then compound 7 produced intramolecular hexagonal cyclization in the presence of Tf2O to obtained 1,2,4-trisubstituted-1,2,3-triazolium salt(8)of the tricyclic system.The structure was characterized by 1H NMR,13C NMR and MS(ESI).

关 键 词：三氮唑 卡宾前体盐 分子内六元环化 并三环体系 合成 

分 类 号：O621.251[理学—有机化学]