注意缺陷多动障碍患儿事件相关电位P300潜伏期的探讨  

Study of event-related potentials P300 latency in children with attention deficit hyperactivity disorder

作　　者：冯硕[1] 刘肖予 张烨[1] 李尔珍[1] 杨健[1] FENG Shuo;LIU Xiao-yu;ZHANG Ye(Department of Neurology,Affiliated Children’s Hospital,Capital Institute of Pediatrics,Beijing 100020,China)

机构地区：[1]首都儿科研究所附属儿童医院神经内科,北京100020

出　　处：《中国实用儿科杂志》2020年第5期383-386,共4页Chinese Journal of Practical Pediatrics

基　　金：国家重点研发计划重大慢性非传染性疾病防控研究重点专项(2016YFC1306204);北京市科技计划生物医药与生命科学创新培育研究(Z161100000116043)。

摘　　要：目的探讨注意缺陷多动障碍(Attention deficit hyperactivity disorder,ADHD)患儿事件相关电位(eventrelated potentials,ERP)P300的特点。方法采用视觉Odball随机刺激序列对2012-01-01至2018-06-23于首都儿科研究所附属儿童医院就诊的145例6~18岁ADHD患儿进行测试,测定ERP P300潜伏期,分析ADHD患儿ERP P300年龄、性别及异常位点的特点。结果ADHD组患儿ERP异常率为37.2%。ADHD男性患儿事件相关点位P300异常率为41.6%,ADHD女性患儿ERP P300异常率为21.9%,男性患儿明显高于女性患儿,差异具有统计学意义(P=0.042)。通过性别及年龄分组,比较ERP异常率,并未发现随年龄变化的ERP P300异常。ADHD患儿ERP P300异常主要集中在顶中线点(Pz),共14例(25.9%);额中线点、中央中线点及顶中线点(Fz、Cz、Pz)三点均有异常,共12例(22.2%)。结论ADHD患儿ERP异常的男性显著多于女性。在ADHD患儿中,ERP P300异常集中在Pz点,即顶叶的异常最为突出,提示脑网络连接中顶叶功能异常可能是ADHD解剖生物学的核心。Objective To investigate the characteristics of event-related potentials(ERP)P300 in children with atten⁃tion deficit hyperactivity disorder(ADHD).Methods A total of 145 children aged 6 to 18 years with ADHD admitted between January 1,2012 and June 23,2018 to Affiliated Children’s Hospital,Capital Institute of Pediatrics,were tested with visual Odball random stimulation sequence to determine the ERP P300 latency and to analyze the age,gender,and abnormal site characteristics of ERP P300 in children with ADHD.Results The abnormal rate of event-related poten⁃tial in children with ADHD group was 37.2%.The abnormal rate of P300 in the event-related sites of male patients with ADHD was 41.6%,and the abnormal rate of event-related potential P300 in female children with ADHD was 21.9%.The male patients were significantly higher than the female,with statistically significant differences(P=0.042).By grouping based on genders and ages,the abnormal rate of event-related potentials was compared,and no abnormality of event-related potentials P300 was found,which was related to age.The ERP P300 abnormalities in the ADHD group were mainly concentrated in the apical midline point(Pz),totally 14 cases,accounting for 25.9%;the midline point,the central midline point and the top midline point(Fz,Cz,Pz)had abnormalities,totally 12 cases,accounting for 22.2%.Conclusion There are significantly more males with abnormal events-related potentials in children with attention defi⁃cit hyperactivity disorder than female.In children with ADHD,the abnormal event-related potential P300 is concentrat⁃ed at the Pz point,that is,the abnormality of the parietal lobe is the most prominent,suggesting that the abnormal function of parietal lobe in brain network connection may be the core of ADHD anatomy biology.

关 键 词：儿童 事件相关电位P300 注意缺陷多动障碍 

分 类 号：R72[医药卫生—儿科]