芪参益气滴丸联合西医治疗冠心病心功能不全对心功能及NT-proBNP的影响  

Effects of Qishenyiqi Dropping Pills Combined with Western Medicine in the Treatment of Coronary Heart Disease Heart Function Insufficiency on Heart Function and NT-proBNP

作　　者：肖平 陈毅文 XIAO Ping;CHEN Yiwen(Shaoguan Railway Hospital,Shaoguan 512000,China;不详)

机构地区：[1]广东省韶关市铁路医院,广东韶关512000 [2]广东省韶关市北江监狱医院,广东韶关512000

出　　处：《中国医学创新》2020年第13期57-61,共5页Medical Innovation of China

摘　　要：目的:探讨芪参益气滴丸在冠心病心功能不全治疗中的应用效果及对NT-proBNP的影响。方法:选择2018年6月-2019年3月就诊于本院诊断为冠心病心功能不全的患者96例为研究对象。应用随机数字表法将其分为常规组和芪参组,每组48例。常规组接受西医常规治疗,芪参组接受芪参益气滴丸联合西医常规治疗。比较两组的治疗效果、血清炎性因子水平、LVEF、NT-proBNP及不良反应发生情况。结果:治疗过程中,两组hs-CRP及TNF-α水平均呈降低趋势,差异均有统计学意义(P<0.05);治疗12周后,芪参组hs-CRP及TNF-α水平均低于常规组,差异均有统计学意义(P<0.05)。治疗过程中,两组LVEF均呈升高趋势,NT-proBNP均呈降低趋势,差异均有统计学意义(P<0.05);治疗12周后,芪参组LVEF高于常规组,NT-proBNP低于常规组,差异均有统计学意义(P<0.05)。治疗12周后,芪参组治疗总有效率为93.75%,明显高于常规组的70.83%,差异有统计学意义(P<0.05)。治疗12周后,芪参组不良反应发生率为6.25%,虽低于常规组的12.50%,但两组比较差异无统计学意义(P>0.05)。结论:冠心病心功能不全的治疗中,芪参益气滴丸可显著提高临床治疗效果,且不增加药物不良反应的发生率。Objective: To explore the application effect of Qishenyiqi Dropping Pills in the treatment of coronary heart disease with cardiac insufficiency and its effect on NT-proBNP. Method: A total of 96 patients with coronary heart disease and cardiac insufficiency diagnosed in our hospital from June 2018 to March 2019 were selected as the study subjects. The random number table method was used to divide them into the conventional group and the Qishen group, 48 cases in each group. The conventional group received conventional treatment by western medicine, Qishen group received Qishenyiqi Dropping Pills combined with traditional western medicine treatment. The therapeutic effect, serum inflammatory factor levels, LVEF, NT-proBNP and adverse reactions were compared between the two groups. Result: During the treatment, hs-CRP and TNF-α levels in the two groups showed a decreasing trend, and the differences were statistically significant(P<0.05). After 12 weeks of treatment, hs-CRP and TNF-α levels in Qishen group were lower than those in the conventional group, with statistically significant differences(P<0.05). During the treatment, LVEF in both groups showed an increasing trend and NTproBNP showed a decreasing trend, with statistically significant differences(P<0.05). After 12 weeks of treatment, LVEF in Qishen group was higher than that in the conventional group, and NT-proBNP was lower than that in the conventional group, with statistically significant differences(P<0.05). After 12 weeks of treatment, the total effective rate of Qishen group was 93.75%, significantly higher than 70.83% of the conventional group, and the difference was statistically significant(P<0.05). After 12 weeks of treatment, the incidence of adverse reactions in Qishen group was 6.25%, which was lower than 12.50% in the conventional group, but the difference between the two groups was not statistically significant(P>0.05). Conclusion: In the treatment of coronary heart disease with heart dysfunction, Qishenyiqi Dropping Pills can significantly

关 键 词：芪参益气滴丸 冠心病 心功能不全 N末端B型利钠肽原 

分 类 号：R541.4[医药卫生—心血管疾病]