α1受体阻滞剂用于上尿路结石体外碎石后石街排石治疗的临床药学评价  

Clinical pharmacological evaluation of the treatment of upper urinary calculi with lithotripsy after extracorporeal lithotripsy

作　　者：倪旭[1] 张年宝[1] Ni Xu;Zhang Nianbao(Department of Pharmacy,the People's Hospital of Xuancheng City,Xuancheng 242000,China)

机构地区：[1]安徽省宣城市人民医院药学部,242000

出　　处：《国际泌尿系统杂志》2020年第3期416-418,共3页International Journal of Urology and Nephrology

基　　金：吴阶平医学基金(LCYX-Q008)。

摘　　要：目的对比坦索罗辛及特拉唑嗪用于上尿路结石体外碎石后石街保守排石治疗的有效性及安全性,为临床安全合理用药提供依据。方法回顾性分析本院2017年1月至2017年12月上尿路结石行体外碎石治疗后发生输尿管下段石街患者共77例,依所服用α1受体阻滞剂种类分为坦索罗辛组42例及特拉唑嗪组35例,对比分析两组排石疗效以及心血管不良反应发生情况。结果坦索罗辛组结石排出率为80.95%(34/42),显著高于特拉唑嗪组的60.00%(21/35)(P<0.05);坦索罗辛组平均肾绞痛发作频次为0.50次,显著低于特拉唑嗪组为2.11次(P<0.05);坦索罗辛组平均肾绞痛最长持续时间为0.71 h,显著低于特拉唑嗪组的1.78 h(P<0.05);坦索罗辛组体位性低血压发生率为9.52%(4/42)、心悸发生率为11.90%(5/42)、晕厥发生率为0.00%,均显著低于特拉唑嗪组的31.43%(11/35)、34.29%(12/35)、11.43%(4/35)(P<0.05)。结论坦索罗辛用于输尿管结石体外冲击波碎石后石街的保守排石疗效显著优于特拉唑嗪,同时具有较低的心血管系统不良反应发生风险,值得临床推广应用。Objective To compare the efficacy and safety of tamsulosin and terazosin in the treatment of upper urinary stones after lithotripsy with lithotripsy,and to provide evidence for clinical safety and rational drug use.Methods A retrospective analysis was made on 77 patients with lower ureteral stone streets after upper urinary stones were treated with extracorporeal lithotripsy in our hospital from January 2017 to December 2017.According to the type of castor 1 receptor blockers used,there were 42 cases in the tensoroxine group and 35 cases in the trazozine group.The curative effect and the occurrence of cardiovascular adverse reactions were compared between the groups.Results The stone removal rate of the tamsulosin group was 80.95%,which was significantly higher than that of the trazozine group(60.00%)(P<0.05).The average frequency of renal colic attack in the tamsulosin group was 0.50 times,which was significantly lower than that in the terazosin group was 2.11 times(P<0.05).The average longest duration of renal colic in the tamsulosin group was 0.71 hours,significantly lower than that in the trazosin group(P<0.05).The incidence of postural hypotension was 9.52%,palpitation 11.90%and syncope 0.0%in the tamsulosin group,all significantly lower than 31.43%,34.29%and 11.43%in the trazozine group(P<0.05).Conclusions The effect of tamsulosin on conservative lithotripsy in ureteral calculi after extracorporeal shockwave lithotripsy is su-perior to that of terazosin.

关 键 词：尿路结石 肾上腺素能α-1受体拮抗剂 碎石术 

分 类 号：R699[医药卫生—泌尿科学]