中性粒细胞明胶酶相关载脂蛋白、肾损伤分子-1及胱抑素-C对ICU脓毒症患者并发急性肾损伤的诊断效能  

Diagnostic Efficacy of NGAL,KIM-1 and Cys-C in Patients with Sepsis Complicated with Acute Renal Injury in ICU

作　　者：林长亮 冯星火[1] LIN Changliang;FENG Xinghuo(Department of Critical Care Medicine,The People’s Hospital of Liaoning Province,Shenyang 110016,Liaoning Province,China)

机构地区：[1]辽宁省人民医院重症医学科,沈阳110016

出　　处：《中国实用乡村医生杂志》2020年第5期54-56,共3页Chinese Practical Journal of Rural Doctor

摘　　要：目的探讨中性粒细胞明胶酶相关载脂蛋白(NGAL)、肾损伤分子-1(KIM-1)及胱抑素-C(Cys-C)对ICU脓毒症患者并发急性肾损伤(AKI)的诊断效能。方法选择2018—2019年辽宁省人民医院收治的脓毒症患者114例,依据患者是否出现AKI分为损伤组61例和非损伤组53例。以双抗体夹心酶标免疫分析法检测患者不同时间点NGAL、KIM-1和Cys-C水平,评估三者对AKI的诊断效能。结果两组不同时间点NGAL、KIM-1和Cys-C水平差异均有统计学意义(P<0.05)。三种标志物单独检测的诊断效能以KIM-1最佳,三种标志物联合检测的诊断效能优于单一标志物检测。结论血清NGAL、KIM-1和Cys-C均可早期预测脓毒症患者出现AKI,推荐三种标志物联合检测,以提高诊断效能。Objective To compare the diagnostic efficacy of Neutmphil Gelatinase Associated Lipocalin(NGAL),Kidney Injury Molecule-l(KIM-1)and Cystatin-C(Cys-C)in predicting acute renal injury(AKI)in patients with sepsis in intensive care unit(ICU).Methods A total of 114 patients with sepsis admitted to The People’s Hospital of Liaoning Province from 2018 to 2019 were divided into injury group(61 cases)and non injury group(53 cases)according to whether there is AKI.The levels of NGAL,KIM-1 and Cys-C at different time points were detected by double antibody sandwich enzyme immunoassay,and their diagnostic efficacy for AKI was compared.Results There were significant differences in NGAL,KIM-1 and Cys-C levels between the two groups at different time points(P<0.05).Among the three markers,KIM-1 is the best,but the combined detection efficiency of three markers is significantly better than single marker.Conclusion Serum NGAL,KIM-1 and Cys-C can predict the occurrence of AKI in sepsis in the early stage.We recommend the combined detection of three markers to improve the diagnostic efficiency.

关 键 词：脓毒症 并发症 肾损伤 急性 中性粒细胞明胶酶相关载脂蛋白 肾损伤分子-l 胱抑素-C 

分 类 号：R44[医药卫生—诊断学]