肾素-血管紧张素-醛固酮系统在高血压和心力衰竭疾病的相关研究进展  

RAAS crossroad from arterial hypertension to heart failure

作　　者：孙春金 曹梦灵 关宏锏[2] 赵光贤[1] 金春子[1] SUN Chun-Jin;CAO Meng-ling;GUAN Hong-jian;ZHAO Guang-xian;JIN Chun-zi(Department of Cardiology,Yanbian University Hospital,Yanji 133000,China;Department of Neurology,Yanbian University Hospital,Yanji 133000,China)

机构地区：[1]延边大学附属医院心内科,吉林省延吉市133000 [2]延边大学附属医院神经内科,吉林省延吉市133000

出　　处：《中国心血管病研究》2020年第5期446-450,共5页Chinese Journal of Cardiovascular Research

基　　金：国家自然科学基金(81760075、81460039);吉林省卫生厅项目(2018J100)。

摘　　要：心力衰竭是目前心血管疾病导致死亡的最重要原因之一,高血压是心力衰竭的主要危险因素.这两种疾病都有共同的病理生理机制.其中,肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosterone system,RAAS)过度激活是高血压导致心力衰竭的关键危险因素.RAAS可调控血压稳定性、细胞外液的稳态及心血管重塑,因此,RAAS已成为心血管疾病重要治疗靶点.本文比较了几个常用降压药物及临床试验的相关数据,针对高血压向心力衰竭转变过程中RAAS轴的相关机制的研究进展作一综述.Heart failure is one of the most important causes of death caused by cardiovascular disease.Hypertension is the main risk factor of heart failure.Both the two diseases have the same pathophysiological mechanisms.Among them,over-activation of the renin-angiotensin-aldosterone system(RAAS)is a key risk factor of hypertension leading to heart failure.RAAS can regulate blood pressure stability,extracellular fluid homeostasis and cardiovascular remodeling.Therefore,RAAS has become an important therapeutic target for cardiovascular disease.This article compared the data of several commonly used antihypertensive drugs and clinical trials and review the research progress of the RAAS axis in the process of hypertension to heart failure.

关 键 词：心力衰竭 高血压 肾素-血管紧张素-醛固酮系统 

分 类 号：R544.1[医药卫生—心血管疾病]