头孢曲松致过敏性休克1例  

A Case of Anaphylactic Shock Caused by Ceftriaxone

作　　者：余雄杰[1] 张静[1] 李园[1] 黄年旭[1] 陈锦华[1] YU Xiong-jie;ZHANG Jing;LI Yuan;HUANG Nian-xu;CHEN Jin-hua(Department of Pharmacy,Wuhan Asian Heart Hospital,Wuhan,Hubei Province,430022 China)

机构地区：[1]武汉亚洲心脏病医院药学部,湖北武汉430022

出　　处：《中外医疗》2020年第8期61-63,共3页China & Foreign Medical Treatment

摘　　要：1例15岁女性患者,于2019年5月5日因发现心脏病3年,发热、咳嗽、心慌1月入院,临床诊断为心脏瓣膜病二尖瓣腱索断裂、前后瓣脱垂并中-重度关闭不全心功能III级感染性心内膜炎待查。患者既往有"止咳糖浆"过敏史,入院后完善相关检查,给予头孢曲松抗感染治疗,在头孢曲松抗感染治疗10 min后出现口唇发紫,四肢抽搐,两眼上翻,呼之不应等表现,考虑药物相关过敏性反应,立即予以停药,并大抢救,吸氧、气管插管、补容、抗过敏、大剂量血管活性药物维持循环、对症支持治疗后症状逐渐好转。A 15-year-old female patient was admitted as of May 5,2019 to the hospital in one month for 3 years of heart disease, fever, cough, and palpitation. She was diagnosed with heart valve disease, mitral valve chordae rupture, anterior and posterior valve prolapse, and moderate-severe closure insufficiency grade III infective endocarditis pending investigation.The patient had a history of "cough syrup" allergies. After admission, she completed relevant examinations and was given ceftriaxone anti-infection treatment. After 10 min of ceftriaxone anti-infection treatment, her lips became purple, her limbs twitched, her eyes turned up, and had no response, considering drug-related allergic reactions, immediately discontinue the drug and rescue the patient, oxygen inhalation, tracheal intubation, volume replenishment, anti-allergy, high-dose vasoactive drugs to maintain circulation, symptomatic supportive treatment symptoms gradually improve.

关 键 词：头孢曲松 药品不良反应 过敏性休克 临床药师 

分 类 号：R593.1[医药卫生—内科学]