国产牛肺表面活性物质治疗早产儿呼吸窘迫综合征的临床效果  

Clinical Effect of Domestic Bovine Lung Surfactant on Premature Infants with Respiratory Distress Syndrome

作　　者：胥苗林 宋存红 XU Miao-lin;SONG Cun-hong(Department of Pediatrics,Liaocheng Central Hospital,Liaocheng,Shandong Province,252000 China;Department of Pediatrics,Yanggu County People's Hospital,Yanggu,Shandong Province,252300 China)

机构地区：[1]聊城市中心医院儿科,山东聊城252000 [2]山东省阳谷县人民医院儿科,山东阳谷252300

出　　处：《中外医疗》2020年第7期15-18,共4页China & Foreign Medical Treatment

摘　　要：目的探讨国产牛肺表面活性物质治疗早产儿呼吸窘迫综合征的临床效果。方法在该院2016年7月—2018年4月期间诊治的呼吸窘迫综合征早产儿中方便选取106例作研究对象,将使用猪肺表面活性物质治疗者设为对照组(n=53),将使用国产牛肺表面活性物质治疗者设为研究组(n=53),就2组早产儿并发症发生率、住院费用以及血气分析指标变化进行统计学分析。结果①用药后24 h,两组早产儿的PaCO2水平均明显下降,而PaO2水平明显升高,与用药前相比差异有统计学意义(PaO2t=43.672、44.991,P=0.000,0.000;PaCO2t=9.285、9.122,P=0.000,0.000),但二者组间比较差异无统计学意义(PaO2t=0.329、0.485,P=0.371、0.314;PaCO2=0.045、0.227,P=0.482、0.411);②研究组早产儿中并发症发生率、病死率与对照组相比均差异无统计学意义(χ^2=0.364、0.231、1.161、0.364、0.190、2.000,P=0.546、0.631、0.281、0.546、0.663、0.157);③研究组早产儿住院时间、氧疗时间与对照组相比无统计学差异(t=0.268、0.257,P=0.395、0.399),而该组总治疗费(28483.45±1145.59)元用少于对照组的(31462.53±1089.47)元(t=13.719,P=0.000)。结论国产牛肺表面活性物质治疗早产儿呼吸窘迫综合征的临床效果突出,安全性、有效性兼备,且价格低廉。Objective To investigate the clinical effect of domestic bovine lung surfactant on premature infants with respiratory distress syndrome.Methods A total of 106 preterm infants with respiratory distress syndrome diagnosed and treated in the hospital from July 2016 to April 2018 were convenient selected as the research subjects.Those treated with porcine lung surfactant were used as the control group(n=53).The domestic bovine pulmonary surfactant treatment group was set as the study group(n=53),and statistical analysis was performed on the incidence of complications,hospitalization costs,and changes in blood gas analysis indexes in the two groups.Results 1.After 24 hours of administration,the levels of PaCO2 in the two groups of premature infants decreased significantly,while the levels of PaO2 increased significantly,which was statistically different from that before administration(PaO2t=43.672,44.991,both P=0.000,0.000;PaCO2t=9.285,9.122,P=0.000,0.000),but there was no statistical difference between the two groups(PaO2t=0.329,0.485,P=0.371,0.314;PaCO2=0.045,0.227,P=0.482,0.411);2.There was no statistical difference in the incidence and mortality of the disease concurrent in premature infants in the study group,compared with the control group(χ^2=0.364,0.231,1.161,0.364,0.190,2.000,P=0.546,0.631,0.281,0.546,0.663,0.157);3.There was no statistically significant difference in the hospitalization time and oxygen therapy time of premature infants in the study group compared with the control group(t=0.268,0.257,P=0.395,0.399),and the total treatment cost of this group(28483.45±1145.59)yuan was less than(31462.53±1089.47)yuan in the control group(t=13.719,P=0.000).Conclusion The domestic bovine pulmonary surfactant is effective in treating premature infants with respiratory distress syndrome.It has both safety and effectiveness,and is inexpensive.

关 键 词：国产牛肺表面活性物质 早产儿 猪肺表面活性物质 呼吸窘迫综合征 并发症 

分 类 号：R722.6[医药卫生—儿科]