Ⅰ型糖尿病患者血睾酮与低度炎症状态及微血管病变的关系分析  

Analysis of the Relationship between Blood Testosterone and Low Inflammation and Microangiopathy in Patients with Type 1 Diabetes

作　　者：蔡填[1] 王素妍 李桂平[1] 赖玉林[1] CAI Tian;WANG Su-yan;LI Gui-ping;LAI Yu-lin(Department of Endocrinology,the Third People's Hospital of Huizhou City,Huizhou,Guangdong Province,516000 China)

机构地区：[1]惠州市第三人民医院内分泌科,广东惠州516000

出　　处：《糖尿病新世界》2020年第4期4-6,共3页Diabetes New World Magazine

基　　金：惠州市科技计划项目(2017Y161)。

摘　　要：目的探讨Ⅰ型糖尿病患者血睾酮与临床指标包括性别、年龄、炎性指标以及微血管病变的关系。方法随机对该院2015年1月-2019年1月间诊治的Ⅰ型糖尿病患者50例,根据患者的性别、年龄、炎性指标CRP、血脂以及是否合并微血管病变(糖尿病肾病、糖尿病周围神经病变、糖尿病视网膜病变)进行分组,对比各组的血总睾酮水平以及游离睾酮指数(FAI)和睾酮分泌指数(TSI)的差异。结果不同性别组的总睾酮水平以及游离睾酮指数和睾酮分泌指数比较差异无统计学意义(P>0.05);年龄段为>50岁组的总睾酮水平降低较为明显,为(10.25±1.58)nmol/L,其次是30~50岁组,FAI和TSI亦有所降低,两组与<30岁组比较差异有统计学意义(P<0.05);根据血清CRP水平,将患者分为低度炎症组(CRP≥2.0 mg/L)和非低度炎症组,低度炎症组的血清总睾酮水平较低,为(12.25±1.48)nmol/L,明显低于非低度炎症组(P<0.05),同时两组患者的FAI和TSI差异有统计学意义(P<0.05);合并微血管病变组的血睾酮水平明显降低,同时FAI和TSI亦低于无微血管病变组(P<0.05)。结论Ⅰ型糖尿病患者存在明显的睾酮代谢紊乱,并与体内的炎症状态关系密切,共同促进糖尿病并发症的发生。Objective To investigate the relationship between blood testosterone and clinical indicators including type,age,inflammatory indicators and microangiopathy in patients with type 1 diabetes.Methods From January 2015 to January 2019 Fifty patients with type I diabetes diagnosed and treated in our hospital were randomly divided into two groups according to their gender,age,inflammatory index CRP,blood lipids,and whether they were associated with microangiopathy(diabetic nephropathy,diabetic peripheral neuropathy,and diabetic retinopathy).The total blood testosterone levels and differences in free testosterone index(FAI)and testosterone secretion index(TSI)of the groups were different.Results There was no significant difference in the total testosterone levels,free testosterone index and testosterone secretion index between different gender groups(P>0.05);the total testosterone levels in the age group>50 years were significantly reduced,which was(10.25±1.58)nmol/L,followed by the 30-50 years old group,FAI and TSI also decreased,the differences between the two groups were statistically significant compared with the<30 year old group(P<0.05);patients were classified as low according to serum CRP levels;the level of serum total testosterone in the low-inflammatory group(CRP≥2.0 mg/L)and the non-low-inflammatory group was low(12.25±1.48)nmol/L,which was significantly lower than the non-low-inflammatory group(P<0.05),and there were statistical differences in FAI and TSI between the two groups of patients(P<0.05);blood testosterone levels in the combined microangiopathy group were significantly reduced,while FAI and TSI were also lower than those in the non-microvascular lesion group(P<0.05).Conclusion Patients with type I diabetes have obvious disorder of testosterone metabolism,which is closely related to the inflammatory state in the body,and jointly promote the occurrence of complications of diabetes.

关 键 词：Ⅰ型糖尿病 血睾酮 微血管病变 

分 类 号：R587.2[医药卫生—内分泌]