载中药/天然抗肿瘤药物的超分子药物传递体系研究进展  

Study progress of supramolecular drug delivery system loading traditional Chinese medicine/natural anti-tumor products

作　　者：周振宇 余璇 刘虹[1] 王萌[1] ZHOU Zhen-yu;YU Xuan;LIU Hong;WANG Meng(Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中医药研究院,天津301617

出　　处：《中国中药杂志》2020年第7期1611-1619,共9页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(81873191)。

摘　　要：中药/天然抗肿瘤药物可通过调节机体免疫功能、抑制肿瘤细胞生长、诱导肿瘤细胞凋亡、逆转肿瘤细胞多药耐药等途径发挥作用,但也面临着自身水溶性和稳定性差、缺乏靶向性与生物利用度低等问题,使其临床应用受到限制。近年来,基于分子间非共价键作用的超分子化学的研究与发展,可为解决上述问题提供有效平台。超分子有机大环主体大多具有独特空穴结构、低毒、高稳定性和易于修饰等特点,可基于其与客体药物之间的非共价键作用构建载药体系而有效传递药物达到治疗效果的提高。该文首先对包括以冠醚、环糊精、杯芳烃、葫芦脲四代以及2类新型超分子大环主体进行较为系统的介绍,进而综述了近年来超分子包合在中药/天然抗肿瘤药物递送中实现药物溶解度与稳定性的提高、药物的靶向传递、协同增效和联合给药、新型治疗疗法不同应用的研究进展,以及探究了超分子聚合物、间接结合药物模式和聚轮烷3种其他载药模式的超分子药物传递体系,为药物的高效利用带来了新思路。Ingredients with the anti-tumor property from traditional Chinese medicine/natural products have effects in treating tumor by regulating immune function, inhibiting tumor cell growth, inducing apoptosis, and reversing multidrug resistance. However, the potential of clinical application was restricted by the low hydrophilicity, stability and bioavailability and the lack of targeting. The above problems can be solved through research and development of supramolecular chemistry based on the non-covalent interactions between molecules. The supramolecular macrocyclic host molecules are characterized by a special cavity structure, low toxicity, high stability and rich derivatives spot. The anti-tumor supramolecular drug delivery system loading traditional Chinese medicine/natural products were designed to solve the above problems. In this paper, different supramolecular macrocyclic molecules, including crown ethers, cyclodextrin, calixarene, cucurbituril and two new-type supramolecular macrocyclic hosts were introduced. Their inclusion in enhancing drug solubility and stability, targeting drug delivery, synergies, combinative administration and new-type therapies in different applications, as well as such drug load modes as supramolecular polymers, indirect combination drug mode and polyrotaxanes were also reviewed in this paper, in order to provide a new idea for effective drug utilization.

关 键 词：抗肿瘤 中药/天然药物 超分子大环主体 药物递送 

分 类 号：R283.6[医药卫生—中药学]