基于隐结构模型的名老中医药专家辨证论治京津冀地区慢性萎缩性胃炎用药规律研究  

Study on medication regularity of chronic atrophic gastritis in Beijing-Tianjin-Hebei region based on latent structure model

作　　者：徐伟超[1] 许玉龙[2] 张增博 李佃贵[1] 刘建平[1] 杜艳茹[1] 郎晓猛[1] 李刚[1] 贾蕊[4] 杨倩[1] XU Wei-chao;XU Yu-long;ZHANG Zeng-bo;LI Dian-gui;LIU Jian-ping;DU Yan-ru;LANG Xiao-meng;LI Gang;JIA Rui;YANG Qian(Department of Spleen and Stomach,Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang 050011,China;College of Information Engineering,Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Beijing Institute of Technology,Beijing 100081,China;Hebei University of Chinese Medicine,Shijiazhuang 050200,China)

机构地区：[1]河北省中医院脾胃病科,河北石家庄050011 [2]河南中医药大学信息工程学院,河南郑州450000 [3]北京理工大学,北京100081 [4]河北中医学院,河北石家庄050200

出　　处：《中国中药杂志》2020年第7期1691-1697,共7页China Journal of Chinese Materia Medica

基　　金：国家中医临床研究基地建设项目(国中医药办科技函[2018]18);国家中医药管理局第三届国医大师传承工作室及全国名中医药专家传承工作室建设项目(国中医药人教函[2012]149);国家自然科学基金项目(81703946);河北省省级科技计划项目(19277754D);河北省中医药管理局项目(2017032)。

摘　　要：基于隐结构模型探讨名老中医药专家辨证论治京津冀地区慢性萎缩性胃炎的病因病机、证候分布及用药规律。提取已构建的名老中医药专家脾胃病数据库中京津冀地区慢性萎缩性胃炎医案279例,运用孔明灯3.1.2软件分别构建慢性萎缩性胃炎症状和药物的隐结构模型,进行隐类诠释。运用SAS 10.0软件对药-药、药-症进行关联规则挖掘。结果显示京津冀地区慢性萎缩性胃炎患者的体质特点为"浊毒内蕴兼伤阴",常见证型为浊毒内蕴证、胃阴不足证、肝胃郁热证、肝胃气滞证、胃络瘀阻证、脾胃虚弱证。常用药物为半边莲、半枝莲、豆蔻、砂仁、茯苓、板蓝根、茵陈、全蝎、黄连、百合、乌药、芦根、麦冬、藿香、佩兰、厚朴、枳实。常用方剂为百合乌药散、当归芍药散、逍遥丸、香苏散、大承气汤、左金丸、清中汤、枳实导滞丸等。结果表明应用隐结构模型与关联分析进行名老中医药专家经验研究,符合现代中医"中医药学+X"的研究方向。所得结论有效挖掘了名老中医药专家经验,为青年中医医师辨证论治慢性萎缩性胃炎提供了数据化、可视化的临床参考与组方配伍。To explore the etiology, pathogenesis, distribution of syndromes and the rule of medication of chronic atrophic gastritis(CAG) in Beijing-Tianjin-Hebei region based on the latent structure model. Chronic atrophic gastritis of 279 cases in Beijing-Tianjin-Hebei region were extracted from the established database of spleen and stomach diseases of famous veteran Chinese medicine experts. The latent structure models of symptoms and drugs of chronic atrophic gastritis were constructed by using Lantern 3.1.2 software, and the latent structure models were interpreted. SAS 10.0 software was used to mine association rules of drugs and symptoms. The constitutional characteristics of patients with chronic atrophic gastritis in Beijing-Tianjin-Hebei region were "turbid toxin and damaging Yin". The common syndromes were turbid toxin, deficiency of stomach Yin, stagnation of liver and stomach, stagnation of liver and stomach Qi, obstruction of stomach collaterals and blood stasis, and weakness of spleen and stomach. Common medicines are Lobeliae Chinensis Herba, Scutellariae Barbatae Herba, Amomi Fructus Rotundus, Amomi Fructus, Poria, Isatidis Radix, Artemisiae Scopariae Herba, Scorpio, Coptidis Rhizoma, Lilii Bulbus, Linderae Radix, Phragmitis Rhizoma, Ophiopogonis Radix, Pogostemonis Herba, Eupatorii Herba, Magnoliae Officinalis Cortex, Aurantii Fructus Immaturus. Common prescriptions are Baihe Wuyao Powder, Danggui Shaoyao Powder, Xiaoyao Pills, Xiangsu Powder, Dachengqi Decoction, Zuojin Pills, Qingzhong Decoction, Zhishi Daozhi Pills, etc. The application of latent structure model and correlation analysis in the empirical study of famous and veteran Chinese medicine experts is in line with the research direction of modern Chinese medicine "traditional Chinese medicine + X". The conclusions obtained effectively tap the experience of famous and veteran TCM experts, and provide a data and visual clinical reference and prescription compatibility for young TCM physicians in the treatment of chronic atrophic gastritis based on

关 键 词：隐结构模型 慢性萎缩性胃炎 名老中医药专家 京津冀地区 医案 数据挖掘 

分 类 号：TP311.13[自动化与计算机技术—计算机软件与理论] R259[自动化与计算机技术—计算机科学与技术]