白鲜皮挥发油中潜在活性成分的网络药理学研究  

Network pharmacology study on potential active components in volatile oil of Dictamni Cortex

作　　者：童黄锦[1,2,3] 石芸[3] 吉敬 高珣 杨东姨 杜沙莉 李伟东[3] 秦昆明 TONG Huang-jin;SHI Yun;JI Jing;GAO Xun;YANG Dong-yi;DU Sha-li;LI Wei-dong;QIN Kun-ming(Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210028,China;Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028,China;School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China;School of Pharmacy,Jiangsu Ocean University,Lianyungang 222005,China;Nanjing Haiyuan Prepared Slices of Chinese Crude Drugs Co.,Ltd.,Nanjing 210061,China)

机构地区：[1]南京中医药大学附属中西医结合医院,江苏南京210028 [2]江苏省中医药研究院,江苏南京210028 [3]南京中医药大学药学院,江苏南京210023 [4]江苏海洋大学药学院,江苏连云港222005 [5]南京海源中药饮片有限公司,江苏南京210061

出　　处：《中国中药杂志》2020年第5期1135-1141,共7页China Journal of Chinese Materia Medica

基　　金：南京药学会-常州四药医院药学科研基金项目(2018YX006);江苏海洋大学大学生实践创新训练计划项目;江苏海洋大学人才引进科研基金项目(KQ17016)。

摘　　要：中药白鲜皮挥发油中含有多种化学成分,采用网络药理学方法可以揭示"成分-靶点-疾病"复杂网络关系,揭示白鲜皮的药效作用机制。该研究通过Swiss Target Prediction数据库预测作用靶点;通过STRING数据库构建蛋白相互作用网络;采用Cytoscape软件构建"成分-靶点-疾病"网络。结果显示:白鲜皮抗菌、抗炎、抗过敏等作用与麝香草酚甲醚、榄香醇、茴香脑、侧柏烯、肉豆蔻醚等成分密切相关,且各个成分的相关作用靶点相互交联,共同发挥多靶点药效作用。该研究为中药白鲜皮的药效物质基础研究与质量控制评价奠定了基础,并为进一步深入揭示其作用机制提供了科学依据。There are many chemical components in the volatile oil of Dictamni Cortex.The complex network relationship of"component-target-disease"can be revealed by using the network pharmacology method,and the mechanism of the efficacy of Dictamni Cortex can be revealed.In this study,we used Swiss Target Prediction database to predict the target of action,STRING database to build protein interaction network,and Cytoscape software to build"component-target-disease"network.The results showed that the antibacterial,anti-inflammatory and antiallergic effects of Dictamni Cortex were closely related to the components of thymol methyl ether,elemenol,anethole,and the related targets of each component were cross-linked to play a multi-target pharmacodynamic role.This study laid a foundation for the study of the effective substance basis and quality control evaluation of the Dictamni Cortex,and provided a scientific basis for further revealing its mechanism.

关 键 词：白鲜皮 挥发油 作用靶点 网络药理学 

分 类 号：R285[医药卫生—中药学]