髓源性抑制细胞与肺癌转移前微环境的形成  

Myeloid-derived suppressor cells and formation of lung cancer′s premetastatic niche

作　　者：罗斌[1] 姚嘉良 田建辉[1,2] 刘嘉湘[1] LUO Bin;YAO Jia-Liang;TIAN Jian-Hui;LIU Jia-Xiang(Department of Oncology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院肿瘤科,上海200032 [2]上海市中医药研究院中医肿瘤研究所,上海200032

出　　处：《中国免疫学杂志》2020年第9期1136-1139,1144,共5页Chinese Journal of Immunology

基　　金：国家自然基金面上项目(No.81774166,No.81973517);上海市卫生健康委员会优秀学术带头人计划(2017BR044)。

摘　　要：转移是恶性肿瘤导致死亡的主要原因,目前尚无针对转移的药物。转移前微环境是肿瘤发生转移前在远端器官形成的适宜"土壤",有益于循环肿瘤细胞的定植。而转移前微环境的主要特征是免疫抑制,髓源性抑制细胞是近年来发现的具有抑制特异性和非特异性免疫的重要负性调控细胞。本综述对髓源性抑制细胞在转移前微环境的作用机制及潜在的干预靶点进行总结,以期揭示髓源性抑制细胞对转移前微环境的影响,进而为干预恶性肿瘤的转移提供有效的思路。Metastasis is the leading cause of death in malignant tumors,but there are no drugs for metastasis currently.A suitable "soil" of distant organs for the formation of metastasis is named pre-metastatic niche(PMN),which is beneficial to the colonization of circulating tumor cells.The main feature of PMN is immunosuppression,and myeloid-derived suppressor cells(MDSC) has been discovered in recent years,which plays an important negative regulatory that could inhibit specific and non-specific immunity.This review summarizes the mechanism of immunosuppressive effect of MDSC in the PMN and the potential intervention targets,in order to reveal the effect of MDSC on PMN,and to provide an effective way to intervene the metastasis of malignant tumors.

关 键 词：髓源性抑制细胞 转移前微环境 肺癌 肿瘤免疫微环境 区域免疫 

分 类 号：R563.8[医药卫生—呼吸系统]