环境表观遗传学与支气管哮喘的研究进展  

Research progress of environmental epigenetics and asthma

作　　者：杨宝霞 郑百红[1] 黎萍[2] 张云峰[1] YANG Bao-Xia;ZHENG Bai-Hong;LI Ping;ZHANG Yun-Feng(Department of Pediatrics,Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林大学第二医院儿科,长春130041 [2]吉林大学第二医院发育儿科

出　　处：《中国免疫学杂志》2020年第10期1275-1278,共4页Chinese Journal of Immunology

基　　金：吉林省科技厅自然科学基金(20160101046JC);吉林省省直卫生专项局项目(3D518V433429)资助。

摘　　要：支气管哮喘的发病率呈逐年上升趋势。近年来,表观遗传机制介导的空气污染物、过敏原和微生物等环境暴露诱发哮喘的病因病机备受关注,阐明这些环境因素的表观遗传效应可为哮喘的诊断和防治提供科学依据和潜在标志物。本文综述了环境表观遗传学与哮喘的最新研究进展。Asthma prevalence has been increased with years.Epigenetic influence of environmental exposures on asthma etiology and pathogenesis,such as air pollution,allergens,and environmental microbiome has been focused recently.To expound the epigentics of evirommental exposures might provide scientific basis and biomarkers for diagnosis and prevention of asthma.This article summarized the latest advances of environmental epigenetics and asthma.

关 键 词：哮喘 表观遗传 过敏原 空气污染 微生物 

分 类 号：R392.9[医药卫生—免疫学]