阿托莫兰针剂(即注射用还原型谷胱甘肽)对小儿慢性活动性乙型肝炎的临床疗效分析  

Analysis of the Clinical Efficacy of Atomoran Injection(Reduced Glutathione for Injection) on Chronic Active Hepatitis B in Children

作　　者：陈虹谨 CHEN Hong-jin(Department of Infectious Diseases,People's Hospital of Xishuangbanna Prefecture,Yunnan Province,661000 China)

机构地区：[1]云南省西双版纳州人民医院感染科,云南西双版纳661000

出　　处：《系统医学》2020年第5期79-81,共3页Systems Medicine

摘　　要：目的观察分析阿托莫兰针剂(即注射用还原型谷胱甘肽)对小儿慢性活动性乙型肝炎的临床疗效。方法选择在该院进行治疗的小儿慢性活动性乙型肝炎患儿46例,选择时间为2018年5月-2019年5月,将患儿随意分为常规组和实验组,常规组行门冬氨酸钾镁治疗,实验组行阿拓莫兰针剂治疗,比较分析两组患儿的肝功能情况、临床指标恢复时间及临床疗效。结果实验组患儿的AST、ALT、Tbil、TBA等肝功能指标恢复情况较常规组更为优异,差异有统计学意义(P<0.05)。实验组患儿恶心呕吐、乏力、肝区不适等临床指标恢复时间较常规组明显更短,差异有统计学意义(P<0.05)。实验组患儿治疗有效率为91.30%(21例),常规组患儿治疗有效率为65.22%(15例),实验组患儿治疗有效率较常规组明显更高,差异有统计学意义(χ^2=4.600,P<0.05)。结论通过阿拓莫兰针剂对小儿慢性活动性乙型肝炎进行治疗,可有效改善患儿肝功能指标,缩短临床症状改善时间,治疗有效率呈现明显增高趋势,具有一定的临床使用价值。Objective To observe and analyze the clinical effect of atomoran injection(reduced glutathione for injection) on chronic active hepatitis B in children. Methods 46 children with chronic active hepatitis B who were treated in the hospital were selected from May 2018 to May 2019. The children were randomly divided into the conventional group and the experimental group. Treatment with potassium aspartate and magnesium was performed in the experimental group with atomolam injection, and the liver function, clinical index recovery time, and clinical efficacy of the two groups were compared and analyzed. Results The recovery of liver function indexes such as AST,ALT, Tbil, TBA in the experimental group was better than that in the conventional group, and the difference was statistically significant(P <0.05). The recovery time of clinical indicators such as nausea, vomiting, fatigue, and liver discomfort in the experimental group was significantly shorter than that in the conventional group, and the difference was statistically significant(P<0.05). The effective rate of treatment in the experimental group was 91.30%(21 cases),and the effective rate of treatment in the conventional group was 65.22%(15 cases). The effective rate of treatment in the experimental group was significantly higher than that in the conventional group(χ^2=4.600, P<0.05). Conclusion The treatment of chronic active hepatitis B in children by Atomolam injection can effectively improve the liver function index of children, shorten the improvement time of clinical symptoms, and the treatment efficiency is obviously increased, which has certain clinical value.

关 键 词：小儿慢性活动性肝炎 临床疗效 阿拓莫兰针剂 

分 类 号：R4[医药卫生—临床医学]