树脂D001×7绿色催化Biginelli反应一锅合成3,4-二氢嘧啶-2-酮类化合物的研究  

One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones over D001×7 resin via Biginelli reaction

作　　者：蒋卫华[1] 滕巧巧 孟启[1] 陶永新[1] JIANG Wei-hua;TENG Qiao-qiao;MENG Qi;TAO Yong-xin(School of Petrochemical Engineering,Changzhou Universily,Changzhou 213164,China)

机构地区：[1]常州大学石油化工学院,江苏常州213164

出　　处：《现代化工》2020年第5期90-94,共5页Modern Chemical Industry

基　　金：国家自然科学基金(21775013)。

摘　　要：比较了D001×7树脂和几种常见的催化剂催化Biginelli反应的效果,优化了D001×7树脂催化Biginelli反应的条件。结果表明,以D001×7树脂为催化剂、乙醇作溶剂,在催化剂的用量为0.02 g/(1 mmo L醛)、80℃条件下回流反应2 h,产率高达92.8%。催化剂反复使用4次,产率仍达到83.6%。通过优化反应条件合成了一系列的3,4-二氢嘧啶-2-酮类衍生物,产物均经1H-NMR与IR进行了表征和熔点的确认。Effects of Biginelli reaction over D001×7 resin and several common catalysts are compared.The conditions of Biginelli reaction catalyzed by D001×7 resin are optimized.It is shown that the yield is as high as 92.8%when D001×7 resin is used as catalyst,ethanol is used as solvent,the adding amount of catalyst is 0.02 g/(1 mmo L aldehyde)and reaction lasts for 2 h with reflux at 80℃.The yield can still maintain at 83.6%after the catalyst is used repeatedly for 4 times.Through optimizing reaction conditions,a series of 3,4-dihydropyrimidin-2(1 H)-ones derivatives are synthesized,and all products are characterized and confirmed by melting point,1 HNMR and IR.

关 键 词：D001×7树脂 BIGINELLI反应 绿色催化 一锅反应 3 4-二氢嘧啶-2-酮 

分 类 号：O626[理学—有机化学]