无创机械通气在老年肺动脉高压患者呼吸衰竭治疗中改善氧合状况和BNP水平的影响  

Effect of Non-invasive Mechanical Ventilation on Improving Oxygenation and BNP Levels in Elderly Patients with Pulmonary Hypertension

作　　者：吴金凤 赖敏 WU Jin-feng;LAI Min(Department of Respiratory Medicine,Shenzhen Hengsheng Hospital,Shenzhen,Guangdong Province,518102 China)

机构地区：[1]深圳恒生医院呼吸内科,广东深圳518102

出　　处：《中外医疗》2020年第10期37-38,76,共3页China & Foreign Medical Treatment

摘　　要：目的探讨老年肺动脉高压合并呼吸衰竭患者采用无创机械通气治疗对氧合状况和脑钠肽(BNP)的改善情况。方法便利选择该院2017年9月-2018年9月的肺动脉高压合并呼吸衰竭的患者共80例,分为两组各40例,对照组采用有创机械通气治疗,观察组采用无创机械通气治疗,对比两组患者的氧浓度(FiO2)、氧合指数(OI)、动脉血氧饱和度(SaO2)、动脉血二氧化碳分压(PaCO2)、动脉血氧分压(PaO2)、动脉肺泡氧分压比(A/aPO2)、肺动脉高压、BNP水平。结果观察组治疗后的氧合指标[FiO2(0.31±0.03)、OI (15.34±1.27)、SaO2(90.04±7.42)%、PaCO2(41.06±4.35)mmHg、PaO2(80.34±7.46)mmHg和A/aPO2(0.28±0.01)]、肺动脉高压(30.07±4.73)mmHg、BNP(80.07±30.04)ng/L水平较对照组对应指标[FiO2(0.42±0.06)、OI (23.31±2.37)、SaO2(80.01±8.41)%、PaCO2(51.03±5.34)mmHg、PaO2(59.84±4.37)mmHg和A/aPO2(0.21±0.02)、肺动脉高压(42.61±4.35)mmHg、BNP (135.27±25.39)ng/L]改善明显(t=10.970、18.750、5.656、9.155、15.000、19.800、12.340、8.876,P<0.05)。结论无创机械通气治疗老年肺动脉高压合并呼吸衰竭患者后可有效的改善氧合状况和BNP水平。Objective To investigate the improvement of oxygenation status and brain natriuretic peptide(BNP) in elderly patients with pulmonary hypertension and respiratory failure by non-invasive mechanical ventilation. Methods Convenient selection a total of 80 patients with pulmonary hypertension and respiratory failure from September 2017 to September 2018 were enrolled in our hospital. They were divided into two groups, 40 patients in each group. The control group was treated with invasive mechanical ventilation, and the observation group was treated with non-invasive mechanical ventilation.Oxygen concentration(FiO2), oxygenation index(OI), arterial oxygen saturation(SaO2), arterial blood carbon dioxide partial pressure(PaCO2), arterial oxygen partial pressure(PaO2), arterial alveolar oxygen partial pressure ratio(A/aPO2),pulmonary hypertension, BNP levels. Results The oxygenation index of the observation group after treatment [FiO2(0.31 ±0.03), OI(15.34±1.27), SaO2(90.04±7.42)%, PaCO2(41.06±4.35)mmHg, PaO2(80.34±7.46)mmHg and A/APO2(0.28±0.01)], pulmonary hypertension(30.07±4.73)mmHg, BNP(80.07±30.04)ng/L level compared with the control group [FiO2(0.42±0.06), OI(23.31±2.37), SaO2(80.01 ±8.41)%, PaCO2(51.03 ±5.34)mmHg, PaO2(59.84 ±4.37)mmHg and A/aPO2(0.21 ±0.02), pulmonary hypertension(42.61 ±4.35)mmHg, BNP(135.27 ±25.39)ng/L] improvement obvious(t =10.970,18.750,5.656,9.155,15.000,19.800,12.340,8.876, P <0.05). Conclusion Noninvasive mechanical ventilation can effectively improve oxygenation and BNP levels in elderly patients with pulmonary hypertension and respiratory failure.

关 键 词：肺动脉高压 呼吸衰竭 无创机械通气 氧合状况 脑钠肽 

分 类 号：R563.8[医药卫生—呼吸系统] R544.1[医药卫生—内科学]