下肢缺血性疼痛的镇痛药物治疗及其进展  

Progress of analgesics for ischemic pain of lower limbs

作　　者：张雷[1,2] 欧鹏[4] 朱洁婷 舒畅 李鑫[1,2] ZHANG Lei;OU Peng;ZHU Jie-ting;SHU Chang;LI Xin(Department of Vascular Surgery,Second Xiangya Hospital,Central South University,Changsha 410011;Institute of Vascular Diseases,Central South University,Changsha 410011;Vascular Surgery,National Cardiovascular Center,Fuwai Hospital,Chinese Academy of Medical Sciences,Beijing 100037;Department of Pain,Second Xiangya Hospital,Central South University,Changsha 410011)

机构地区：[1]中南大学湘雅二医院血管外科,长沙410011 [2]中南大学血管病研究所,长沙410011 [3]国家心血管病中心中国医学科学院阜外医院血管外科,北京100037 [4]中南大学湘雅二医院疼痛科,长沙410011

出　　处：《中南药学》2020年第5期815-821,共7页Central South Pharmacy

摘　　要：下肢剧烈疼痛是下肢动脉缺血性疾病患者的常见症状。一般镇痛药物治疗的效果不理想,严重影响了患者的生活质量,甚至加重合并心脑血管疾病患者的主要心血管事件发生几率。本文综合已报道的文献,分析下肢动脉缺血疼痛的机制,介绍目前较常见的可用于临床治疗下肢缺血性疼痛的镇痛药物,并结合镇痛药物的特点和下肢缺血疼痛的机制介绍适用于临床的镇痛效果较好的药物,同时对这些药物的研究和应用进展进行综述。The severe pain of lower limbs is often seen in patients who suffer from lower limb ischemia.The effect of various analgesics is usually not satisfactory,and the pain may lower patients’life quality.Moreover,long-time pain will even increase the rate of major adverse cardiovascular events.We reviewed literatures of analgesics and lower limb ischemia mechanism and introduced commonly used analgesics and analysed their mechanism for lower limb ischemia,and familiarized the characteristics of analgesics to find new drugs or methods to deal with patients’severe pain.

关 键 词：下肢动脉疾病 下肢缺血性疼痛 镇痛药物 疼痛治疗 

分 类 号：R971.1[医药卫生—药品]