不同种族/民族乙型肝炎分子流行病学研究进展  

Progress in researches on molecular epidemiology of hepatitis B virus in various racial/ethnic populations

作　　者：董哲 李雪梅 赵智娴[3] 许琳[3] 余文[3] 康文玉[3] 李琼芬[3] DONG Zhe;LI Xue-mei;ZHAO Zhi-xian(School of Public Health,Kunming Medical University,Kunming,Yunnan Province 650500,China;不详)

机构地区：[1]昆明医科大学公共卫生学院,云南昆明650500 [2]云南第二人民医院体检中心 [3]云南省疾病预防控制中心免疫规划所

出　　处：《中国公共卫生》2020年第4期650-653,共4页Chinese Journal of Public Health

摘　　要：乙型肝炎(乙肝)是全球性的公共卫生问题,感染率在不同人群中差异大,优势基因型也各不相同。乙型肝炎病毒(HBV)感染率的变化和分子流行病学特征对乙肝防控至关重要。本文讨论HBV感染的最新情况,对国内外已开展的不同民族乙型肝炎分子流行病学研究进行简要综述,旨在为我国开展乙肝分子流行病学研究和乙肝防控提供参考。综述结果显示,国外针对HBV基因型地理分布和种族分布的研究较国内多,已有研究发现种族和基因型之间的相关性较地理的更强。但相关研究的结果存在相反结论,多数研究显示其中存在相关性,也有一部分显示没有关联,且研究人群较局限,不同种族和民族乙型肝炎的分子流行病学有待进一步研究。Hepatitis B virus(HBV) infection is a global public health problem;the infection rate varies greatly among different populations and dominant genotypes are also different. The change in HBV infection rate and the epidemiological characteristics of hepatitis B are essential for the prevention and control of hepatitis B. This article discusses the latest situation of HBV infection, and briefly reviews molecular epidemiology researches on hepatitis B in different ethnic groups at home and abroad for providing references to molecular epidemiology researches and the prevention and control of hepatitis B in China. The results of literature study show that there are more studies on the geographical distribution and ethnic distribution of HBV genotypes abroad than in China. The correlation between race and genotype is stronger than that of geography and genotype. However, there are opposite conclusions in the studies and the populations been studied are limited.The molecular epidemiology of hepatitis B in different races and ethnic groups needs further study.

关 键 词：乙肝 基因型 种族 民族 分子流行病学 

分 类 号：R512.62[医药卫生—内科学]