腹腔镜辅助小切口阑尾切除术对急性阑尾炎患者降钙素原、C-反应蛋白、白细胞介素-6及CD3^+、CD4^+、CD8^+水平的影响  

Effects of laparoscopic appendectomy with small incision on PCT,CRP,IL-6,CD3^+,CD4^+,and CD8^+levels in patients with acute appendicitis

作　　者：文喜陵 江菊芬 赵坤[1] WEN Xiling;JIANG Jufen;ZHAO Kun(Department of General Surgery,Songgang People's Hospital of Bao’an District,Shenzhen,Guangdong 518105,China)

机构地区：[1]广东省深圳市宝安区松岗人民医院普通外科,广东深圳518105

出　　处：《中国医学工程》2019年第6期20-24,共5页China Medical Engineering

摘　　要：目的研究腹腔镜辅助小切口阑尾切除术对急性阑尾炎患者降钙素原(PCT)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)及CD3^+、CD4^+、CD8^+水平的影响。方法以2016年2月至2018年2月该院收治的急性阑尾炎患者90例为研究对象,将其以随机数字表法均分成研究组和对照组。对照组予以传统开腹切除术治疗,研究组则予以腹腔镜辅助小切口阑尾切除术治疗。分别比较两组各项手术指标水平,治疗前后血清PCT、CRP、IL-6及CD3^+、CD4^+、CD8^+水平,术后并发症发生情况。结果研究组手术时间、术后进食时间、术后排气时间、住院时间相比对照组较低(均P<0.05)。治疗后研究组血清PCT、CRP、IL-6水平相比对照组较低(均P<0.05)。治疗后研究组CD3^+、CD4^+水平相比对照组较高,而CD8^+水平相比对照组较低(均P<0.05)。研究组术后并发症发生率相比对照组较高(P<0.05)。结论腹腔镜辅助小切口阑尾切除术治疗急性阑尾炎患者效果明显,有利于促进患者早日康复,不会造成严重炎症反应,且对机体免疫力损伤较小,术后并发症发生风险较低,安全性较佳,值得临床推广应用。【Objective】To study and analyze the effects of laparoscopic appendectomy with small incision on the levels of PCT,CRP,IL-6,CD3^+,CD4^+and CD8^+in patients with acute appendicitis.【Methods】A total of 90 patients with acute appendicitis treated in our hospital from February 2016 to February 2018 were studied.The control group received conventional laparotomy and the study group received laparoscopic appendectomy with minor incision.The levels of various surgical indicators in the two groups were compared,and the serum levels of PCT,CRP,IL-6,CD3^+,CD4^+,CD8^+,and the occurrence of postoperative complications were compared before and after treatment.【Results】The operative time,postoperative feeding time,postoperative exhaust time and hospitalization time in the study group were lower than those in the control group(all P<0.05).After treatment,serum PCT,CRP,and IL-6 levels in the study group were lower than those in the control group(all P<0.05).After treatment,CD3^+and CD4^+levels in the study group were higher than those in the control group,while CD8^+levels were lower than those in the control group(all P<0.05).The incidence of postoperative complications in the study group was higher than that in the control group(P<0.05).【Conclusion】Laparoscopic appendectomy with small incision is effective in the treatment of patients with acute appendicitis,which is conducive to the early recovery of the patients;it will not cause serious inflammatory response,and it will cause less damage to the body's immunity and lower risk of postoperative complications.It is safe and worthy of clinical application.

关 键 词：急性阑尾炎 腹腔镜 小切口阑尾切除术 炎症反应 细胞免疫 

分 类 号：R656.8[医药卫生—外科学]