亚临床认知障碍慢性阻塞性肺疾病患者脑白质改变基于体系分析统计学分析  

Statistical analysis of white matter changes in patients with chronic obstructive pulmonary disease and subclinical cognitive impairment based on voxel analysis

作　　者：汪春荣 刘勇[2] 詹亚峰 高德宏 邹立秋 彭珂文 陈济明 邱士军[5] WANG Chunrong;LIU Yong;ZHAN Yafeng;GAO Dehong;ZOU Liqiu;PENG Kewen;CHEN Jiming;QIU Shijun(Department of Radiology,Huazhong University of Science and Technology Union Shenzhen Hospital,Guangdong Province,Shenzhen518052,China;Brainnetome Center,Institute of Automation,Chinese Academy of Sciences,Beijing100190,China;School of Biomedical Engineering,Southern Medical University,Guangdong Province,Guangzhou510515,China;Department of Respiration,Huazhong University of Science and Technology Union Shenzhen Hospital,Guangdong Province,Shenzhen518052,China;Department of Radiology,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou510405,China)

机构地区：[1]华中科技大学协和深圳医院放射科,广东深圳518052 [2]中国科学院自动化研究所脑网络研究中心,北京100190 [3]南方医科大学生物医学工程学院,广东广州510515 [4]华中科技大学协和深圳医院呼吸科,广东深圳518052 [5]广州中医药大学第一附属医院影像科,广东广州510405

出　　处：《中国医药导报》2020年第13期114-117,共4页China Medical Herald

基　　金：广东省深圳市教育(卫生)科技资助项目(南科研卫2016037号);广东省深圳市卫生计生系统科研项目(SZFZ2017087)。

摘　　要：目的探讨稳定期亚临床认知障碍慢性阻塞性肺疾病(COPD)患者脑白质结构的改变。方法选择2012年7月~2015年3月华中科技大学协和深圳医院(以下简称“我院”)就诊COPD患者60例作为COPD组,另选择同期于我院进行健康体检人群62名作为对照组。收集两组人群一般资料、生理及神经心理学资料,并利用基于体素水平分析(VBA)分析两组人群全脑脑白质微观结构改变。结果COPD组吸烟时间长于对照组,差异有统计学意义(P<0.05)。简易精神状态量表、蒙特利尔认知评估量表总分及视空间与执行功能、命名及延迟记忆得分显著低于对照组,差异有统计学意义(P<0.05)。COPD组左侧枕中回、右侧辅助运动区、左侧颞上回及右侧小脑后叶区域白质FA值显著低于对照组,差异有高度统计学意义(P<0.01)。结论稳定期COPD患者脑白质FA值异常,纤维微观结构完整性被破坏,应引起临床重视。Objective To investigate the changes of white matter structure in patients with stable subclinical cognitive impairment chronic obstructive pulmonary disease(COPD).Methods From July 2012 to March 2015,60 patients with COPD treated in Huazhong University of Science and Technology Union Shenzhen Hospital(hereinafter referred to as“our hospital”)were selected as the COPD group,while a total of 62 healthy people who underwent a physical examination in our hospital during the same period were selected as the control group.The general data,physiological and neuropsychological data of the two groups were collected,while the changes in the whole brain white matter microstructure of the two groups were analyzed by the voxel level analysis(VBA).Results The smoking time of the COPD group was longer than that of the control group,and the difference was statistically significant(P<0.05).The total scores of mini mental state examination,Montreal cognitive assess ment and the visual space and executive function,naming and delayed memory scores were significantly lower than those of the control group,the differences were statistically significant(P<0.05).In the COPD group,the white matter FA values in the left middle occipital gyrus,right auxiliary motor area,left superior temporal gyrus,and right posterior cerebellar area were significantly lower than those in the control group,and the differences were highly statistically significant(P<0.01).Conclusion FA value of the white matter in patients with COPD in the stable phase is abnormal,and the microstructural integrity of the fibers is destroyed,which should be paid attention to clinically.

关 键 词：基于体素水平分析 脑白质 慢性阻塞性肺疾病 认知障碍 

分 类 号：R563.05[医药卫生—呼吸系统]