逍遥散联合针灸治疗肝郁脾虚型无排卵性不孕症的临床观察  

Clinical Observation of Xiaoyaosan(逍遥散)Combined with Acupuncture in Treating Anovulatory Infertility Caused by Liver Depression and Spleen Deficiency

作　　者：罗红燕 刘奇英[2] 付磊[2] 吴小平 杨望[1] 周昕俐 LUO Hong-yan;LIU Qi-ying;FU Lei;WU Xiao-ping;YANG Wang;ZHOU Xin-li(Hunan University of Traditional Chinese Medicine,Changsha Hunan 410208,China;The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha Hunan 410005,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学第二附属医院,湖南长沙410005

出　　处：《中医药导报》2020年第7期61-64,68,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南省中医药管理局资助项目(2016108)。

摘　　要：目的:观察逍遥散联合针灸治疗肝郁脾虚型无排卵性不孕症的临床疗效。方法:将60例肝郁脾虚型无排卵性不孕症患者随机分为A组和B组,每组30例。A组予逍遥散联合针灸治疗,B组予逍遥散联合枸橼酸氯米芬治疗。两组均治疗3个月,比较两组患者治疗前后子宫内膜厚度、最大卵泡直径,及治疗后周期排卵率、临床妊娠率、总有效率和不良反应率。结果:两组患者治疗后子宫内膜厚度与治疗前比较,差异均无统计学意义(P>0.05);两组患者治疗后最大卵泡直径较治疗前均升高,差异均有统计学意义(P<0.05)。提示两种治疗方法均可改善肝郁脾虚型无排卵性不孕症患者的最大卵泡直径,且对子宫内膜厚度无明显影响。两组患者周期排卵率、临床妊娠率比较,差异均无统计学意义(P>0.05);提示两组改善肝郁脾虚型无排卵性不孕症患者周期排卵率、临床妊娠率疗效相当。两组临床疗效比较,差异无统计学意义(P>0.05),提示逍遥散联合针灸治疗肝郁脾虚型无排卵性不孕症均有效,且两种治疗方法疗效相当。两组患者不良反应发生率比较,差异有统计学意义(P<0.05),A组不良反应发生率低于B组,提示逍遥散联合针灸治疗肝郁脾虚型无排卵性不孕症安全性优于逍遥散联合枸橼酸氯米芬。结论:逍遥散联合针灸与逍遥散联合枸橼酸氯米芬治疗肝郁脾虚型无排卵性不孕症疗效无明显差异,但逍遥散联合针灸治疗安全性较高。Objective:To observe the clinical efficacy and safety of Xiaoyaosan combined with acupuncture in the treatment of anovulatory sterility with liver depression and spleen deficiency.Methods:A total of 60 patients with anovulatory infertile caused by liver depression and spleen deficiency were divided into group A and group B,with 30 cases in each group.Group A was treated with Xiaoyaosan combined with acupuncture,and group B was treated with Xiaoyaosan combined with clomiphene citrate.Both groups were treated for 3 months.The endometrial thickness,maximum follicle diameter,ovulation rate,clinical pregnancy rate,total effective rate and adverse reaction rate of the two groups were compared before and after treatment.Results:After treatment,the endometrial thickness of the two groups of patients was not statistically different from that before treatment(P>0.05);the maximum follicle diameter of the two groups of patients were higher than that before treatment,and the difference were statistically significant(P<0.05).It is suggested that both treatment methods can improve the maximum follicle diameter in patients with anovulatory infertility caused by liver stagnation and spleen deficiency,and have no significant effect on the thickness of the endometrium.There was no significant difference between the ovulation rate and clinical pregnancy rate of the two groups of patients(P>0.05).It is suggested that the two groups had the same effect on improving the ovulation rate and clinical pregnancy rate of patients with anovulatory infertility caused by liver depression and spleen deficiency.There was no significant difference in clinical efficacy between the two groups(P>0.05).It is suggested that Xiaoyaosan combined with acupuncture and moxibustion are effective in treating anovulatory infertility with liver stagnation and spleen deficiency,and the two treatment methods are equivalent.There was a statistically significant difference in the incidence of adverse reactions between the two groups(P<0.05).The incidence of adverse

关 键 词：无排卵性不孕症 逍遥散 针灸 肝郁脾虚 

分 类 号：R271.14[医药卫生—中医妇科学]