足细胞上皮-间充质转分化与肾小球疾病  

Podocyte epithelial-mesenchymal transdifferentiation and glomerular disease

作　　者：陈海云 敖英[1] 朱亚男 汪晖[1] CHEN Hai-yun;AO Ying;ZHU Ya-nan;WANG Hui(Hubei Provincial Key Laboratory of Developmentally Originated Diseases,Department of Pharmacology,Basic Medical School of Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学基础医学院药理学系发育源性疾病湖北省重点实验室,武汉430071

出　　处：《临床肾脏病杂志》2020年第5期425-430,共6页Journal Of Clinical Nephrology

基　　金：国家自然科学基金项目(No.81872943,81220108026,81430089,81001466);湖北省卫计委项目(No.WJ2017M002)、湖北省自然科学基金项目(No.2017CFB649)。

摘　　要：目的足细胞对于维持肾小球滤过屏障的稳定性极为重要。足细胞的损伤可导致肾小球滤过功能障碍和相关肾脏疾病的发生。上皮-间质转分化(epithelial-mesenchymal transition,EMT)是足细胞损伤的一种表现形式,也是多种肾小球疾病的始动因素之一。本文主要针对足细胞EMT的定义、具体表现、诱导因素、发生机制及相关肾小球疾病及其防治进行综述,以期阐明足细胞EMT最近研究进展,为相关肾脏疾病的治疗提供参考。Podocytes are extremely important for maintaining the stability of the glomerular filtration barrier,which can lead to glomerular filtration dysfunction and associated kidney disease.Epithelial-mesenchymal transition(EMT)is a manifestation of podocyte injury and one of the initiating factors of various glomerular diseases.This article focuses on the definition,specific manifestations,inducing factors,mechanisms of occurrence and related glomerular diseases of the podocyte EMT and its prevention and treatment,in order to clarify the recent research progress of podocyte EMT,and provide reference for the treatment of related kidney diseases.

关 键 词：足细胞发育不良 足细胞上皮-间质转分化 肾小球疾病 

分 类 号：R692.6[医药卫生—泌尿科学]