靶向能量代谢的抗肿瘤金属配合物  

Antitumor Metal Complexes Targeting Energy Metabolism

作　　者：金素星 郭子建 王晓勇[2] JIN Suxing;GUO Zijian;WANG Xiaoyong(State Key Laboratory of Coordination Chemistry,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China;State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing 210023,China)

机构地区：[1]南京大学化学化工学院配位化学国家重点实验室,江苏南京210023 [2]南京大学生命科学学院医药生物技术国家重点实验室,江苏南京210023

出　　处：《药学进展》2020年第4期280-293,共14页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金(No.31570809,No.21731004)。

摘　　要：癌细胞的能量代谢特征与正常细胞不同,优先选择有氧糖酵解而非氧化磷酸化作为葡萄糖代谢的途径,这种独特的代谢方式可能为抗癌药物提供潜在的作用靶点。以铂类药物为代表的金属配合物因其化学结构多样性和抗肿瘤活性,在癌症治疗中起着非常重要的作用。由于以DNA为作用靶点的现有金属药物容易引起耐药性和系统毒性,故需要设计和发现具有不同作用靶点的新型金属抗肿瘤药物。近年来出现的一类靶向肿瘤细胞能量代谢的金属配合物就体现了为满足这种需求而进行的有益尝试。Energy metabolism of cancer cells is different from that of normal ones and aerobic glycolysis rather than oxidative phosphorylation is preferred in cancer cells as the pathway of glucose metabolism.This unique pathway may thus provide potential targets for anticancer drugs.Metal complexes represented by platinum-based anticancer drugs play an important role in the treatment of cancers due to their distinct structural diversity and antitumor activity.Since the existing metallodrugs with DNA as the target tend to induce drug resistance and systemic toxicity,it is necessary to design and discover novel metal antitumor drugs with alternative targets.The emergence of metal complexes targeting the energy metabolism of tumor cells in recent years represents the pertinent attempt made to meet the demand.

关 键 词：抗肿瘤药物 金属配合物 铂配合物 能量代谢 线粒体 

分 类 号：O641.4[理学—物理化学] R445[理学—化学]