中间体衍生化法与新农药创制——杀虫剂Flupyrimin的创制经纬分析  

The Intermediate Derivatization Method and Novel Agrochemical Discovery——The Discovery of Insecticide Flupyrimin

作　　者：吴峤 杨吉春 刘长令 李淼 WU Qiao;YANG Ji-chun;LIU Chang-ling;LI Miao(State Key Laboratory of the Discovery and Development of Novel Pesticide,Shenyang Sinochem Agrochemicals R&D Co.,Ltd.,Shenyang 110021,China)

机构地区：[1]沈阳中化农药化工研发有限公司,新农药创制与开发国家重点实验室,沈阳110021

出　　处：《农药》2020年第5期313-316,327,共5页Agrochemicals

摘　　要：大量实践证明“中间体衍生化法”可大幅提高新农药创制的成功率。从“中间体衍生化法”的角度对杀虫剂flupyrimin的创制经纬进行分析,具体说明新农药创制过程中选择和利用合适中间体的重要性,也进一步说明了“中间体衍生化法”具有普适性。A lot of practices have proved that‘the intermediate derivatization method’can improve significantly the success rate of new agrochemical discovery.In this paper we summarized the discovery of flupyrimin and demonstrated the importance of selecting and using suitable intermediates in the discovery of novel agrochemicals from the perspective of‘the intermediate derivatization method’and further showed this method is universal.

关 键 词：中间体衍生化法 新农药创制 flupyrimin 中间体 

分 类 号：TQ460.3[化学工程—制药化工]