广州地区轻型和普通型新型冠状病毒肺炎的肝功能表现与临床特点  

Liver Function Manifestation and Clinical Features in Light and Normal type of New Coronavirus Pneumonia in Guangzhou

作　　者：罗纯[1] 谭颖[1] 艾香英[1] 温学良 范慧敏[1] 林路平[1] 谢敏[1] LUO Chun;TAN Ying;AI Xiang-ying;WEN Xue-liang;FAN Hui-min;LIN Lu-ping;XIE Min(Guangzhou Eighth People′s Hosptial,Guangdong,510060)

机构地区：[1]广州市第八人民医院,510060

出　　处：《岭南急诊医学杂志》2020年第2期99-101,共3页Lingnan Journal of Emergency Medicine

基　　金：广东省中医药局项目(2020ZYYJ01)。

摘　　要：目的:初步探讨广州地区轻型和普通型新型冠状病毒肺炎(NCP)的肝功能特点。方法:回顾性分析2020年1月22日至2月27日广州市第八人民医院确诊的297例NCP患者,剔除了可能引起肝功能损害的药物肝、病毒性肝炎、脂肪肝患者,分析215例轻型和普通型NCP患者的入院第1天、6天、12天肝功能特点。最小年龄7岁、最大年龄82例,平均年龄(46.53±15.86岁)。结果:临床表现主要为发热、咳嗽,以干咳为主。首次肺部CT主要表现为肺内磨玻璃影,肝脏影像学未见肿胀等异常影像学表现。新冠肺炎病例显示肝脏损害发生率较低,总胆红素(total bilirubin,TB)异常占6.67%,丙氨酸氨基转移酶(alanine minotransferase,ALT)异常占13.49%,门冬氨酸氨基转移酶(aspartate aminotransferase,AST)异常占17.67%,凝血酶原时间(PT)异常占4.64%。结论:新型肺炎并发肝损害发生率较低,主要表现在转氨酶升高,以轻度多见,总胆红素及凝血酶原时间异常比例极低,且异常程度低,经过积极护肝降酶治疗恢复较快、预后良好。Objective:To investigate the liver function characteristics inlight and normal type of new coronavirus pneumonia(NCP)in Guangzhou area.Methods:A retrospective analysis of 297 patients with NCP confirmed from January 22 to February 27,2020 in the Eighth People′s Hospital of Guangzhou.Excluding patients with drug induced liver injury,viral hepatitis,and fatty liver that may cause liver function damage,liver function features analysis of the remained 215 light andnormal type patients with NCP on the 1st,6th,and 12th days of admission.The minimum age was 7 years old,the maximum age was 82 and the median age was 46.Results:The clinical manifestations are mainly fever and cough,mainly dry cough.The first CT scan of the lung was mainly ground-glass opacity,and liver imaging showed no abnormal imaging such as swelling.NCP cases show a low incidence of liver damage.Total bilirubin(TB)abnormality accounted for 6.67%,alanine minotransferase(ALT)abnormality accounted for 13.49%,aspartate aminotransferase(AST)abnormality accounted for 17.67%,and prothrombin time(PT)abnormality accounted for 4.64%.Conclusion:The incidence of NCP complicated with liver damage is low,mainly manifested in elevated transaminase while most are low-grade,the proportion of abnormal total bilirubin and prothrombin time is extremely low,and the abnormality is low,which can be soon recovered by active liver protection and enzyme reduction treatment with good prognosis.

关 键 词：新型冠状病毒肺炎 肝损害 丙氨酸氨基转移酶 天冬氨酸氨基转移酶 

分 类 号：R563.1[医药卫生—呼吸系统]