肺炎死亡患儿肺组织标本病原学的相关研究  

Study on the etiology of lung tissue from children died of pneumonia

作　　者：胡惠丽[1] 刘钢[1] 杨永弘[2,3] Hu Huili;Liu Gang;Yang Yonghong(Department of Infectious Diseases,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China;Department of Respiration,Shenzhen Children′s Hospital,Shenzhen 518000,Guangdong Province,China;National Clinical Research Center for Respiratory Diseases,Department of Respiratory,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院感染内科,北京100045 [2]深圳市儿童医院呼吸科,广东深圳518000 [3]国家儿童医学中心,首都医科大学附属北京儿童医院呼吸科,国家呼吸系统疾病临床医学研究中心,北京100045

出　　处：《中华实用儿科临床杂志》2020年第7期513-517,共5页Chinese Journal of Applied Clinical Pediatrics

基　　金：北京市医院管理中心儿科学科协同发展中心专项经费(XTZD20180501);北京市医院管理局"登峰"人才培养计划团队(DFL20181201)。

摘　　要：社区获得性肺炎(CAP)仍是儿童时期常见的感染性疾病,其发病率与病死率仍处于较高水平。儿童CAP病原谱多种多样,病原学诊断较困难,各国研究结果存在差异。传统的CAP患者微生物检测方法不能反映肺炎病原学的真实情况。目前,分子生物学方法广泛应用于肺炎的病原学检测,但其价值也与标本来源有关。采用特定的微生物分子诊断技术在肺组织标本中检测病原无疑是最直接、特异、敏感且最有价值的研究手段。但通过肺组织标本进行病原学的研究相对较少。现主要针对肺炎死亡患儿肺组织标本病原学国内外研究现状及优缺点进行阐述。Community-acquired pneumonia(CAP)is still a common infectious disease in childhood,with a high morbidity and mortality.There are diverse pathogenic spectra of CAP in children,making the etiology diagnosis difficult.The research results on CAP′s etiology vary among different countries.The traditional microbial detection method of CAP patients can not accurately detect the pathogen of pneumonia.The value of molecular biological methods that are widely used in the pathogenic detection of pneumonia at present,is also related to the source of the specimen.Specific molecular diagnosis techniques are undoubtedly the most direct,specific,sensitive and valuable method to detect the pathogen in lung tissue samples,but there are little research on the etiology of lung tissues.In this paper,the status,advantages and disadvantages of research on etiology of lung tissue specimens from children died of pneumonia were reviewed.

关 键 词：社区获得性肺炎 病原学 肺组织标本 微生物分子诊断 

分 类 号：R72[医药卫生—儿科]