肺炎链球菌常见血清型国内分离株的耐药克隆变迁  

Changes of drug-resistance clone of common serotype Streptococcus pneumoniae isolates in China

作　　者：刘尊杰[1] 黎全华[2] 杨永弘[3,4] Liu Zunjie;Li Quanhua;Yang Yonghong(Department of Neonatology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China;Department of Ultrasound,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Respiration,Shenzhen Children′s Hospital,Shenzhen 518000,Guangdong Province,China;National Clinical Research Center for Respiratory Diseases,Department of Respiratory,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)

机构地区：[1]首都医科大学附属北京妇产医院新生儿科,北京100026 [2]郑州大学第三附属医院超声科,郑州450052 [3]深圳市儿童医院呼吸科,广东深圳518000 [4]国家儿童医学中心,首都医科大学附属北京儿童医院呼吸科,国家呼吸系统疾病临床医学研究中心,北京100045

出　　处：《中华实用儿科临床杂志》2020年第7期525-528,共4页Chinese Journal of Applied Clinical Pediatrics

摘　　要：肺炎链球菌是儿童社区获得性感染的首位致病病原,可引起侵袭性和非侵袭性疾病。近年来由于抗菌药物的广泛使用,国内肺炎链球菌耐药克隆的替代使耐药问题日趋严重。推广疫苗及合理使用抗生素对控制肺炎链球菌耐药克隆的播散具有重要作用。Streptococcus pneumoniae is the leading pathogen of community-acquired infections in children,and can cause invasive and noninvasive diseases.Due to the overuse of extensive use of antimicrobial agents in recent years,the problem of drug resistance of Streptococcus pneumoniae caused by the resistance clone alternatives becomes increasingly serious.The promotion of vaccine and rational use of antibiotics play an important role in controlling the spread of drug-resistant clones of Streptococcus pneumoniae.

关 键 词：肺炎链球菌 血清型 抗生素耐药 分子流行病学 多位点序列分型 

分 类 号：R446[医药卫生—诊断学]