6群肺炎链球菌新亚型的研究现状  

Current status of the study on new serotypes of serogroup 6 Streptococcus pneumonia

作　　者：刘尊杰[1] 周林[2] 杨永弘[3,4] Liu Zunjie;Zhou Lin;Yang Yonghong(Department of Neonatology,Beijing Obsterics and Gynecology Hospital,Capital Medical University,Beijing 100026,China;Department of Clinical Laboratory,Children′s Hospital Affiliated to Capital Institute of Pediatrics,Beijing 100020,China;Department of Respiration,Shenzhen Children′s Hospital,Shenzhen 518000,Guangdong Province,China;National Clinical Research Center for Respiratory Diseases,Department of Respiratory,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)

机构地区：[1]首都医科大学附属北京妇产医院新生儿科,北京100026 [2]首都儿科研究所附属儿童医院检验中心,北京100020 [3]深圳市儿童医院呼吸科,广东深圳518000 [4]国家儿童医学中心,首都医科大学附属北京儿童医院呼吸科,国家呼吸系统疾病临床医学研究中心,北京100045

出　　处：《中华实用儿科临床杂志》2020年第7期532-535,共4页Chinese Journal of Applied Clinical Pediatrics

摘　　要：6群肺炎链球菌是导致儿童社区感染的常见血清群之一,既往采用荚膜肿胀实验将6群分为6A和6B 2个亚型。随着基因测序分型方法的应用,近年来又发现了6C、6D、6E、6F和6H等新的亚型。肺炎链球菌结合疫苗(PCV)7应用后的国家或地区监测到6C型呈增长的趋势,应引起重视。现就6群肺炎链球菌新亚型的荚膜多糖合成基因、荚膜多糖结构、耐药性及分子流行病学进行阐述。Serogroup 6 Streptococcus pneumoniae is one of the common serogroups that lead to community acquired infections in children,and was divided into 6A and 6B serotypes by quellung reaction.With the application of typing methods by gene sequencing,new serotypes such as 6C,6D,6E,6F and 6H have been discovered in recent years.The increase of 6C subtype in the countries or regions after the introduction of pneumococcal conjugated vaccine(PCV)7 should be emphasized.In this paper,the capsular polysaccharide synthesis genes,structure of capsular polysa-ccharide,antimicrobial resistance and molecular epidemiology of new serotypes of serogroup 6 Streptococcus pneumoniae were discussed.

关 键 词：肺炎链球菌 血清型 抗生素耐药 多位点序列分型 荚膜多糖 

分 类 号：R3[医药卫生—基础医学]