TDRS与靶向性新型抗菌策略  

New antibacterial strategy based on thiol-dependent redox system

作　　者：王朋[1,2] 周靖轩[2] 李涛 陈欢[1] 邹黎黎 董传江[1] WANG Peng;ZHOU Jingxuan;LI Tao;CHEN Huan;ZOU Lili;DONG Chuanjiang(The First College of Clinical Medical Science,China Three Gorges University,Yichang 443000,China;The Institute of Infection and Inflammation,China Three Gorges University,Yichang 443000,China)

机构地区：[1]三峡大学第一临床医学院,宜昌443000 [2]三峡大学感染与炎症损伤研究所,宜昌443000

出　　处：《生命的化学》2020年第3期337-344,共8页Chemistry of Life

基　　金：湖北省自然科学基金(2018CFB490);三峡大学硕士培优基金(2019SSPY108)。

摘　　要：硫醇相关的氧化还原系统(thiol-dependent redox system, TDRS)由硫氧还蛋白系统(thioredoxin system, Trx system)和谷胱甘肽系统(glutaredoxin system, GSH system)组成,存在于多种生物体内,共同维持细胞内氧化还原平衡。原核生物细胞Trx系统中的硫氧还蛋白还原酶(thioredoxin reductase, TrxR)在结构和功能上与哺乳动物TrxR存在着天然差异。这些差异导致了细胞在相同药物作用下发生截然相反的氧化还原反应,使其可以成为潜在的抗菌作用靶点。此外,TrxR作为细菌看家基因trxB编码的蛋白,难以发生突变,故不易产生耐药性,是理想的新型抗菌靶标。本文就TDRS特别是Trx系统靶向性的新型抗菌策略作一综述。Thiol-dependent redox systems widely present in organisms and regulate redox balance intracellular which composed of thioredoxin system and GSH system, in the thioredoxin system, thioredoxin reductase have some natural differences in structure and function between mammals and prokaryotes. These differences lead to a diametrically opposite redox reaction when cells treated by same drug and make thioredoxin reductase become a potential antibacterial target. Moreover, thioredoxin reductase is a promising antibacterial target because it is encoded by the bacterial house-keeping gene trxB, which is difficult to mutate and makes bacteria drug resistance. This paper focuses on the last research progress of new antibacterial strategy based on thioldependent redox system, especially the thioredoxin system.

关 键 词：硫醇相关的氧化还原系统 硫氧还蛋白系统 谷胱甘肽系统 依布硒啉 活性氧 

分 类 号：R378[医药卫生—病原生物学]