Nrf2在动脉粥样硬化中的作用  

The role of Nrf2 in atherosclerosis

作　　者：陈烨 焦波[1] CHEN Ye;JIAO Bo(Department of Pharmacology,School of Pharmaceutical Science,Shandong University,Jinan 250000,China)

机构地区：[1]山东大学药学院药理室,济南250000

出　　处：《生命的化学》2020年第3期411-417,共7页Chemistry of Life

摘　　要：氧化应激是动脉粥样硬化的重要发病机制之一,降低体内氧化应激水平对预防和治疗动脉粥样硬化具有重要意义。核因子-红细胞相关因子2(nuclear factor erythroid 2-related factor 2, Nrf2)属于CNC亮氨酸拉链转录激活因子家族,是内源性抗氧化途径的中枢转录因子,能调节抗氧化因子的表达,对动脉粥样硬化的预防和治疗具有重要作用。近年来,关于Nrf2在动脉粥样硬化中的研究表明,Nrf2可能是动脉粥样硬化的潜在治疗靶点。本文总结了Nrf2在动脉粥样硬化中作用的最新研究进展。Oxidative stress is one of the important pathogenesis of atherosclerosis. Therefore, reducing the level of oxidative stress in vivo is of great significance for the prevention and treatment of atherosclerosis. The transcription factor nuclear transcription factor NF-E2 related factor 2(Nrf2) belongs to the CNC leucine zipper transcription activator family, is a major regulator of antioxidant genes. It is primarily activated in response to oxidative stress and plays an important role to prevent the development of atherosclerosis. Recently, growing evidence indicates that decreased Nrf2 activity contributes to oxidative stress, favoring the pathophysiology of atherosclerosis. Nrf2 may be a potential therapeutic target for atherosclerosis. This review will provide a comprehensive overview on the role of Nrf2 as a contributing factor to atherosclerosis.

关 键 词：NRF2 氧化应激 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]