补气凉血汤联合缩宫素治疗产后出血的效果及对炎性因子和氧化应激的影响  

Effect of Buqi Liangxue Decoction combined with Oxytocin in the treatment of postpartum hemorrhage and its influence on inflammatory factors and oxidative stress

作　　者：周玲[1] 孙红[1] 凌莉[1] 鲁锦 张弘[1] ZHOU Ling;SUN Hong;LING Li;LU Jin;ZHANG Hong(Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Suzhou University,Jiangsu Province,Suzhou215000,China)

机构地区：[1]苏州大学附属第二医院妇产科,江苏苏州215000

出　　处：《中国医药导报》2020年第15期100-103,107,共5页China Medical Herald

基　　金：江苏省卫生计生委科研项目(H2017065)。

摘　　要：目的探讨补气凉血汤联合缩宫素治疗产后出血的效果及对炎性因子和氧化应激的影响。方法回顾性选取2017年8月~2019年8月苏州大学附属第二医院收治的产后出血患者168例,按不同治疗方法将其分为对照组(n=83,缩宫素治疗)和研究组(n=85,补气凉血汤联合缩宫素治疗),两组均治疗7 d。比较两组的临床效果,治疗期间出血情况,产后1、3、7 d子宫复旧情况,治疗前后C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)、脂质过氧化物(LPO)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水平及不良反应发生情况。结果研究组临床总有效率高于对照组(P<0.05)。研究组出血时间短于对照组,失血量、后期出血例数少于对照组(P<0.05)。子宫底高度的组间比较、时间点比较及交互作用差异均有统计学意义(P<0.05);组内比较:随着治疗时间延长,两组子宫底高度均逐渐降低(P<0.05);组间比较:产后1 d,两组子宫底高度比较差异无统计学意义(P>0.05);产后3、7 d,研究组子宫底高度低于对照组(P<0.05)。两组治疗后TNF-α、CRP及IL-8水平均低于治疗前,且研究组低于对照组(P<0.05)。两组治疗后LPO水平低于治疗前,且研究组低于对照组(P<0.05);两组治疗后SOD、GSH-Px水平高于治疗前,且研究组高于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论补气凉血汤联合缩宫素治疗产后出血的效果确切,子宫复旧情况良好,并可降低血清炎性因子水平,减轻患者氧化应激反应,可为临床治疗提供方案参考。Objective To explore the effect of Buqi Liangxue Decoction combined with Oxytocin in the treatment of postpartum hemorrhage and its influence on inflammatory factors and oxidative stress.Methods One hundred and sixty-eight patients with postpartum hemorrhage admitted to the Second Affiliated Hospital of Suzhou University from August 2017 to August 2019 were selected retrospectively.According to the different treatment methods,they were divided into control group(n=83,Oxytocin treatment)and study group(n=85,Buqi Liangxue Decoction combined with Oxytocin treatment).Both groups were treated for 7 days.Clinical effect,bleeding,uterine regurgitation on the 1st,3th and 7th day of postpartum,serum levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),lipid peroxide(LPO),glutathion peroxidase(GSH-Px),superoxide dismutase(SOD)before and after treatment and adverse reactions were compared between two groups.Results Total clinical effective rate of study group was higher than that of control group(P<0.05).The bleeding time of study group was shorter than that of control group,the amount of blood loss and the number of bleeding cases in the later period were less than control group(P<0.05).There were significant differences in the height of uterine fundus among groups,time points and interaction(P<0.05).Intra group comparison:with the prolongation of treatment time,the height of uterine fundus in both groups decreased gradually(P<0.05).Comparison between groups:there was no significant difference between two groups in the height of the uterine fundus on the first day after delivery(P>0.05);on the third and seventh days after delivery,the height of the uterine fundus in study group were lower than those in control group(P<0.05).After treatment,TNF-α,CRP and IL-8 levels in two groups were lower than those before treatment,and study group was lower than control group(P<0.05).LPO level of two groups after treatment was lower than that before treatment,and study group was lower than control group

关 键 词：补气凉血汤 产后出血 缩宫素 临床研究 氧化应激 

分 类 号：R714.461[医药卫生—妇产科学]